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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Stroke. 2020 Aug 6;51(9):2825–2833. doi: 10.1161/STROKEAHA.120.029388

Table 2.

EPVS burden and neuropathologic findings.

EPVS burden
Mild or None Moderate Severe
N (%) 311 (48) 170 (26) 173 (26)
Gross infarcts, n (%) 109 (35) 83 (49) 85 (49)
Microscopic infarcts, n (%) 97 (31) 65 (38) 72 (41)
Atherosclerosis, n (%)
 Severe 21 (7) 9 (5) 12 (7)
 Moderate 53 (17) 38 (22) 34 (20)
 Mild 166 (53) 79 (47) 92 (53)
Arteriolosclerosis, n (%)
 Severe 18 (6) 14 (8) 12 (7)
 Moderate 69 (22) 36 (21) 34 (20)
 Mild 113 (36) 73 (43) 76 (44)
Cerebral amyloid angiopathy, n (%)
 Severe 37 (12) 12 (7) 26 (15)
 Moderate 74 (24) 41 (24) 42 (24)
 Mild 137 (44) 85 (50) 69 (40)
NIA Reagan (Likelihood of AD), n (%)
 High or intermediate 218 (70) 124 (73) 121 (70)
Amyloid plaques, mean (SD) 0.86 (0.66) 0.84 (0.63) 0.85 (0.62)
Neurofibrilary tangles, mean (SD) 0.80 (0.87) 0.78 (0.89) 0.70 (0.84)
Lewy Bodies, n (%) 90 (29) 45 (27) 54 (31)
Hippocampal sclerosis, n (%) 46 (15) 18 (11) 13 (8)
TDP-43 pathology, n (%)
 Inclusions in amygdala, entorhinal cortex or hippocampus CA1, and neocortex 60 (19) 25 (15) 22 (13)
 Inclusions in amygdala, and entorhinal cortex or hippocampus CA1 67 (22) 33 (19) 37 (21)
 Inclusions in amygdala only 51 (16) 40 (24) 25 (14)