Table 2.
Multivariate analysis for NRM, OS, EFS and aGvHD.
| Variable | N = | Multivariate HR | 95% CI | P value* | ++ |
|---|---|---|---|---|---|
| OS | |||||
| Age (continuous) | 315 | 1.01 | 0.98 – 1.05 | 0.400 | |
| Malignant disease (Y/N) | 220/95 | 3.06 | 1.46 – 6.39 | 0.003 | * |
| Donor relation/match: | |||||
| – MRD (reference) | 90 | 1.00 | |||
| – MMRD | 28 | 1.79 | 0.70 – 4.54 | 0.221 | |
| – MMUD | 77 | 1.39 | 0.71 – 2.72 | 0.333 | |
| – MUD | 80 | 1.10 | 0.54 – 2.11 | 0.798 | |
| – Cord Blood | 40 | 1.97 | 0.92 – 4.22 | 0.082 | |
| TBI based conditioning (Y/N) CMV matching | 112/199 | 1.29 | 0.80 – 2.07 | 0.292 | |
| – (Mis)match CMV: R-/D- | 116 | 1.00 | |||
| – (Mis)match CMV: R-/D+ | 40 | 1.31 | 0.58 – 2.96 | 0.525 | |
| – (Mis)match CMV: R+/D- | 59 | 2.32 | 1.29 – 4.18 | 0.004 | * |
| – (Mis)match CMV: R+/D+ | 100 | 1.95 | 1.08 – 3.55 | 0.028 | * |
| CD4+ IR (N/Y) | 107/208 | 2.32 | 1.44 – 3.75 | < 0.001 | * |
| NRM | |||||
| Age (continuous) | 315 | 1.04 | 0.997 – 1.09 | 0.066 | |
| T cell depletion (Y/N) | 208/107 | 1.85 | 0.37 – 9.24 | 0.455 | |
| Donor relation/match | |||||
| – MRD | 90 | 1.00 | |||
| – MMRD | 28 | 2.07 | 0.60 – 7.11 | 0.246 | |
| – MMUD | 77 | 1.43 | 0.51 – 4.03 | 0.497 | |
| – MUD | 80 | 0.73 | 0.22 – 2.36 | 0.596 | |
| – Cord blood (unrelated) | 40 | 2.40 | 0.39 – 14.67 | 0.343 | |
| Recipient CMV serostatus (+/−) | 159/156 | 2.12 | 1.06 – 4.22 | 0.034 | * |
| CD4+ IR (N/Y) | 107/208 | 6.58 | 2.82 – 15.38 | <0.001 | * |
| EFS | |||||
| Malignant disease (Y/N) | 220/95 | 1.80 | 1.08 – 3.03 | 0.025 | * |
| T cell depletion (Y/N) | 208/107 | 1.03 | 0.51 – 2.07 | 0.943 | |
| Donor relation/match: | |||||
| – MRD (reference) | 90 | 1.00 | |||
| – MMRD | 28 | 2.66 | 1.19 – 5.97 | 0.018 | * |
| – MMUD | 77 | 1.92 | 0.98 – 3.77 | 0.056 | |
| – MUD | 80 | 1.67 | 0.87–1.99 | 0.122 | |
| – Cord blood (unrelated) | 40 | 1.72 | 0.78 – 3.78 | 0.177 | |
| TBI based conditioning (Y/N) CMV (mis)match | 112/199 | 0.76 | 0.88 – 1.99 | 0.185 | |
| – R-/D- (reference) | 116 | 1.00 | |||
| – R-/D+ | 40 | 0.97 | 0.49 – 1.95 | 0.938 | |
| – R+/D- | 59 | 1.86 | 1.12 – 3.08 | 0.016 | * |
| – R+/D+ | 100 | 1.50 | 0.92 – 2.44 | 0.013 | |
| No CD4IR (no/yes) | 107/208 | 1.79 | 1.20 – 2.68 | 0.005 | * |
| aGvHD | |||||
| Age categorical: < 10.15 yrs | 155 | 1.00 | |||
| Age categorical: > 10.15 yrs | 160 | 1.46 | 0.88 – 2.42 | 0.140 | |
| malignant/non-malignant) | 220/95 | 1.90 | 0.95 – 3.80 | 0.069 | |
| T cell depletion (Y/N) | 208/107 | 0.56 | 0.25 – 1.25 | 0.157 | |
| Donor relation/match | |||||
| – MRD (reference) | 90 | 1.00 | |||
| – MMRD | 28 | 1.91 | 0.63 – 5.79 | 0.256 | |
| – MMUD | 77 | 1.80 | 0.75 – 4.36 | 0.191 | |
| – MUD | 80 | 1.70 | 0.75 – 3.83 | 0.203 | |
| – Cord Blood | 40 | 3.57 | 1.64 – 7.77 | 0.001 | |
| * | |||||
++
Significance level, p< 0.0