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[Preprint]. 2020 Sep 10:2020.09.09.20178764. [Version 1] doi: 10.1101/2020.09.09.20178764

Metagenomic sequencing to detect respiratory viruses in persons under investigation for COVID-19

Ahmed Babiker, Heath Bradley, Victoria Stittleburg, Autum Key, Colleen Suzanne Kraft, Jesse Waggoner, Anne Piantadosi
PMCID: PMC7491530  PMID: 32935115

Abstract

We used metagenomic next-generation sequencing (mNGS) to assess the frequencies of alternative viral infections in SARS-CoV-2 RT-PCR negative persons under investigations (PUIs) (n=30) and viral co-infections in SARS-CoV-2 RT-PCR positive PUIs (n=45). mNGS identified both co-infections and alternative viral infections that were not detected by routine clinical workup

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