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. Author manuscript; available in PMC: 2020 Sep 16.
Published in final edited form as: Biochemistry. 2019 Feb 6;58(8):1074–1080. doi: 10.1021/acs.biochem.8b01048

Figure 1.

Figure 1.

A. Cartoon representation of antibody-dependent cell-mediated cytotoxicity (ADCC), and B. the crystal structure of the complex of FcγIII receptor and IgG1 Fc. In A. the surface antigen (in yellow) on the target cells interacts with the antibody (in blue) that recognizes the antigen. The Fc receptor (magenta) on the surface of the natural killer (NK) cells can then interact with the antibody. In the crystal structure of the complex (B) (PDB: 1E4K), the FcγIII receptor and IgG1 Fc are also displayed in magenta and blue, respectively. The disulfide bond that links two heavy chains is shown in yellow. The glycosylated sites on FcγIII receptor and IgG1 are shown in spheres.