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. 2020 Apr 23;72(1):213–229. doi: 10.1002/hep.31002

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© 2019 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Motorless myoVb induces the accumulation of apical and basolateral proteins in clustered compartments that display recycling endosome identity. (A) Phospho‐proteins of the ezrin‐radixin‐moesi (ERM) family are not present in myc‐myoVb/Δ1‐1195 clusters (white arrows). Yellow arrowheads indicate BC. (B‐D) Labeling of rip11, rab11a, and rab8 with ANO6 or ABCC2 in HepG2 expressing myc‐myoVb/Δ1‐1195 (white arrows) compared with control. White arrows indicate colocalization of endosomal proteins with BC‐resident protein. The yellow arrowhead indicates juxta‐nuclear staining of rip11 in nonpolarized control cells. (E) Labeling of myc in control and myc‐myoVb/Δ1‐1195 expressing HepG2, fixed after 30 minutes incubation (t = 0 hours) with fluorescently labeled transferrin (388Tf) and after a 2‐hour chase period. 488‐Transferrin localized with myc‐myoVb/Δ1‐1195 clusters (white arrows) at t = 0 hours and at t = 2 hours. Scale bars: 10 μm.