Table 3.

Reduction lesion size and parasite load measured using bioluminescence and qPCR in treated groups compared to untreated group.

Compounds	% Reduction of Lesion Sizes	% Reduction of Parasite Load (Bioluminescence)	% Reduction of Parasite Load (qPCR)
paromomycin (50 mg/kg/QD for 10 days; i.p.)	89	99	99
AmBisome® (10 mg/kg/QAD for 10 days; i.v.)	40	80	73
AmB-CH-TPP nanoparticles (5 mg of AmB/kg/QAD for 10 days; i.v.)	83	99	98
AmB-CH-TPP nanoparticles (2.5 mg of AmB/kg/QAD for 10 days; i.v.)	40	75	71
AmB-CH-TPP nanoparticles (1.25 mg of AmB/kg/QAD for 10 days; i.v.)	29	48	40
CH-TPP nanoparticles mass being equivalent to that in animals receiving the 5 mg/kg dose)	35	65	65