Table 6.

Flux, lag time and the permeability coefficient (kp) for AmB-loaded chitosan nanoparticles.

Formulations	Flux (μg/cm2/h)		Lag Time (h)		Kp (cm/h)
	Uninfected Skin	Infected Skin	Uninfected Skin	Infected Skin	Uninfected Skin	Infected Skin
AmB-CH-TPP nanoparticles	0.06 ± 0.002	0.12 ± 0.005	20 ± 0.1	19.8 ± 0.3	1.8 × 10−5 ± 0.05 × 10−5	3.15 × 10−5 ± 0.15 × 10−5
AmB-CH-Dex nanoparticles	0.04 ± 0.002	0.09 ± 0.002	20.5 ± 0.1	20.3 ± 0.02	0.9 × 10−5 ± 0.05 × 10−5	2.3 × 10−5 ± 0.06 × 10−5
AmB solution	0				0

Data expressed as mean ± SD, n = 5. Statistically significant differences of flux and Kp were observed between uninfected and infected skin for both formulations (p < 0.05 by t-test). No statistically significant difference of lag time was observed between uninfected and infected skin for both formulations (p > 0.05 by using t-test). AmB-CH-TPP nanoparticles (Size = 65 ± 8 nm, Zeta potential = 25.5 ± 1 mV) or AmB-CH-Dex nanoparticles (Size = 170 ± 8 nm, Zeta potential = −13 ± 1 mV).