In the original article, there was a mistake in Table 2 as published. The EXTEM CFT baseline mean (95% confidence interval) for the HES group was slightly incorrect due to a data entry error. The corrected Table 2 appears below.
Table 2.
Rotational thromboelastometry parameters (mean, 95% confidence interval) in dogs (n = 6 per group) with hemorrhagic shock given 20 mL kg−1 of either fresh whole blood (FWB), hydroxyethyl starch 130/0.4 (HES), 4% succinylated gelatin (GELO), or 80 mL kg−1 of balanced isotonic crystalloid (CRYST).
| Parameter | Baseline | Shock | T60 | T180 |
|---|---|---|---|---|
| INTEM CT (sec) | ||||
| FWB | 279.3 (137.5–421.2) | 204.8 (123.1–286.5) | 330.5 (17.2–643.8) | 269.0 (150.7–387.3) |
| CRYST | 171.3 (149.1–193.5) | 160.7 (129.2–192.1) | 162.2 (134.0–190.3) | 159.8 (142.8–176.9) |
| HES | 201.2 (129.1–273.2) | 145.8 (72.2–219.5) | 231.8 (130.4–333.3) | 199.0 (113.0–285.0) |
| GELO | 221.5 (146.0–297.0) | 161.0 (117.0–205.0) | 224.3 (108.6–340.1) | 193.5 (146.5–240.5) |
| INTEM CFT (sec) | ||||
| FWB | 224.2 (143.1–305.2) | 260.3 (180.6–340.0) | 303.8 (102.0–505.7) | 235.3 (178.9–291.8) |
| CRYST | 143.5 (119.1–167.9) | 227.8 (190.9–264.8) | 298.8 (269.5–328.1) | 234.5 (207.6–261.4) |
| HES | 202.8 (106.9–298.8) | 264.0 (168.0–360.0) | 431.5 (287.3–575.7) | 309.2 (221.0–397.3) |
| GELO | 178.2 (128.4–227.9) | 186.2 (114.2–258.1) | 305.5 (211.1–399.9) | 278.7 (178.1–379.2) |
| INTEM α (°) | ||||
| FWB | 54.2 (44.9–63.4) | 54.0 (46.3–61.7) | 52.7 (38.5–66.8) | 56.2 (49.8–62.6) |
| CRYST | 68.0 (65.4–70.6) | 62.7 (57.2–68.1) | 56.8 (53.7–60.0) | 60.7 (59.8–61.5) |
| HES | 60.5 (49.4–71.6) | 56.0 (46.5–65.5) | 50.7 (40.2–61.1) | 53.5 (46.4–60.6) |
| GELO | 61.2 (56.5–65.9) | 61.7 (53.8–69.6) | 53.0 (46.7–59.3) | 56.2 (49.8–62.6) |
| INTEM MCF (mm) | ||||
| FWB | 51.2 (46.9–55.4) | 47.7 (43.0–52.3) | 45.3 (38.3–52.3)+ | 48.2 (44.5–51.8)+ |
| CRYST | 54.2 (50.8–57.5) | 46.3 (43.0–49.7) | 42.2 (39.9–44.4) | 44.0 (41.4–46.6) |
| HES | 50.3 (45.3–55.4) | 44.5 (40.3–48.7) | 37.0 (31.6–42.4)& | 41.0 (36.2–45.8)& |
| GELO | 54.0 (48.3–59.7) | 51.2 (45.8–56.5) | 41.5 (36.0–47.0) | 42.8 (37.2–48.5) |
| INTEM LI60 (%) | ||||
| FWB | 99.0 (97.4–100.6) | 99.7 (98.8–100.5) | 99.7 (98.8–100.5) | 99.2 (97.9–100.4) |
| CRYST | 99.7 (98.8–100.5) | 98.7 (97.6–99.8) | 96.8 (94.7–99.0) | 97.2 (94.4–99.9) |
| HES | 99.2 (97.9–100.4) | 98.5 (96.4–100.6) | 87.8 (67.3–108.4) | 90.0 (74.1–105.9) |
| GELO | 99.5 (98.6–100.4) | 99.7 (99.1–100.2) | 98.3 (94.0–102.6) | 96.5 (87.5–105.5) |
| EXTEM CT (sec) | ||||
| FWB | 52.5 (40.8–64.2) | 75.2 (57.2–93.1) | 64.7 (45.3–84.1)+ | 62.0 (53.1–70.9) |
| CRYST | 54.8 (37.8–71.9) | 66.2 (59.4–72.9) | 72.8 (62.9–82.8)+ | 71.5 (58.7–84.3) |
| HES | 61.8 (40.6–83.0) | 69.0 (56.1–81.9) | 119.3 (57.4–181.3)&,*,# | 82.7 (50.6–114.8) |
| GELO | 47.8 (28.6–67.0) | 55.8 (36.1–75.6) | 76.2 (27.5–124.8)+ | 75.2 (50.6–99.8) |
| EXTEM CFT (sec) | ||||
| FWB | 178.2 (121.5–234.8) | 217.3 (149.5–285.2) | 251.0 (127.6–374.4) | 202.2 (148.5–255.9) |
| CRYST | 129.3 (115.4–143.3) | 184.2 (152.6–215.7) | 246.0 (198.3–293.7) | 221.0 (177.7–264.3) |
| HES | 187.2 (106.0–268.3) | 208.0 (137.8–278.2) | 373.4 (179.9–566.9) | 437.3 (0.0–918.6) |
| GELO | 139.3 (102.6–176.1) | 165.0 (115.5–214.5) | 230.4 (167.7–293.1) | 263.3 (174.5–352.1) |
| EXTEM α (°) | ||||
| FWB | 59.8 (53.5–66.1) | 60.0 (55.9–64.1) | 55.8 (48.8–62.9) | 58.3 (54.4–62.3) |
| CRYST | 66.5 (64.4–68.6) | 63.3 (60.9–65.8) | 59.3 (54.2–64.5) | 60.8 (59.0–62.6) |
| HES | 61.7 (55.1–68.2) | 61.8 (56.4–67.2) | 46.2 (28.6–63.8) | 53.0 (39.8–66.2) |
| GELO | 65.7 (62.8–68.5) | 63.5 (59.9–67.1) | 49.5 (32.7–66.3) | 56.0 (52.5–59.5) |
| EXTEM MCF (mm) | ||||
| FWB | 50.5 (46.3–54.7) | 44.7 (39.6–49.7) | 45.3 (38.6–52.1)+ | 47.0 (43.4–50.6) |
| CRYST | 54.7 (52.1–57.2) | 45.7 (42.1–49.3) | 39.0 (33.3–44.7) | 39.3 (34.7–44.0) |
| HES | 49.3 (42.7–55.9) | 42.5 (33.4–51.6) | 31.2 (20.5–41.9)& | 37.8 (28.6–47.1) |
| GELO | 54.3 (47.8–60.8) | 50.0 (43.4–56.6)ß | 39.0 (26.6–51.4) | 40.3 (31.9–48.8) |
| EXTEM TPI | ||||
| FWB | 18.8 (12.7–25.0) | 12.5 (6.7–18.3) | 12.3 (5.6–19.0) | 14.0 (9.6–18.4) |
| CRYST | 28.5 (22.8–34.2) | 14.3 (10.5–18.2) | 8.2 (5.6–10.8) | 9.3 (6.1–12.6) |
| HES | 20.2 (7.4–32.9) | 14.2 (1.1–27.3) | 4.8 (2.0–7.6) | 8.2 (1.4–14.9) |
| GELO | 28.8 (15.3–42.4) | 21.0 (10.3–31.7) | 11.2 (5.3–17.1) | 9.5 (4.2–14.8) |
| EXTEM LI60 (%) | ||||
| FWB | 89.3 (66.9–111.7) | 78.7 (48.1–109.3) | 90.7 (70.7–110.7) | 91.0 (78.2–103.8) |
| CRYST | 99.0 (97.9–100.1) | 87.7 (73.0–102.3) | 84.7 (52.9–116.5) | 78.8 (58.5–99.2) |
| HES | 98.3 (95.5–101.2) | 83.3 (56.1–110.6) | 74.3 (36.5–112.2) | 84.3 (56.2–112.5) |
| GELO | 97.5 (93.8–101.2) | 86.7 (65.3–108.1) | 75.8 (49.2–102.5) | 72.5 (42.5–102.5) |
| FIBTEM MCF (mm) | ||||
| FWB | 4.3 (3.5–5.2) | 3.5 (2.4–4.6) | 3.3 (1.5–5.2) | 2.8 (1.0–4.6) |
| CRYST | 6.0 (3.1–8.9) | 4.7 (1.9–7.5) | 2.8 (1.0–4.6) | 3.2 (1.2–5.1) |
| HES | 5.0 (2.6–7.4) | 2.0 (0.0–4.9) | 0.7 (0.0–2.4) | 2.2 (0.0–5.2) |
| GELO | 4.8 (3.3–6.4) | 3.8 (2.3–5.4) | 2.0 (0.2–3.8) | 2.7 (1.1–4.2) |
Fluid was delivered directly after Shock time point.
Significantly different to FWB;
Significantly different to CRYST;
Significantly different to HES;
Significantly different to GELO (Bonferroni–Holm corrected P-value < 0.05). α, alpha angle; CFT, clot formation time; CT, clotting time; LI60, lysis index at 60 min; MCF, maximum clot firmness; TPI, thrombodynamic potential index.
In the original article, there was a mistake in Table 5 as published. The EXTEM CFT baseline mean (95% confidence interval) was slightly incorrect due to a data entry error. The corrected Table 5 appears below.
Table 5.
Platelet closure time and count, rotational thromboelastometry, and plasma coagulation assay parameters (mean, 95% confidence interval) in dogs (n = 24) with hemorrhagic shock.
| Parameter | Baseline | Shock | P value* |
|---|---|---|---|
| Platelet Closure Time (sec) | 83.4 (77.6–89.1) | 69.0 (65.2–72.8) | <0.001 |
| Estimated Platelet Count (x109 L−1) | 134.3 (124.7–143.9) | 119.4 (106.3–132.5) | 0.057 |
| INTEM CT (sec) | 218.3 (180.9–255.7) | 168.1 (143.2–193.0) | <0.001 |
| INTEM CFT (sec) | 158.5 (135.9–181.1) | 234.6 (203.6–265.6) | <0.001 |
| INTEM α (°) | 61.0 (57.4–64.5) | 58.6 (55.3–61.9) | 0.067 |
| INTEM MCF (mm) | 52.4 (50.5–54.3) | 47.4 (45.4–49.4) | <0.001 |
| INTEM LI60 (%) | 99.3 (98.9–99.8) | 99.1 (98.6–99.7) | 0.458 |
| EXTEM CT (sec) | 54.3 (47.3–61.2) | 66.5 (60.1–73.0) | <0.001 |
| EXTEM CFT (sec) | 148.0 (125.3–170.7) | 193.6 (170.5–216.8) | <0.001 |
| EXTEM α (°) | 63.4 (61.2–65.6) | 62.2 (60.5–63.8) | 0.117 |
| EXTEM MCF (mm) | 52.2 (50.0–54.4) | 45.7 (43.0–48.4) | <0.001 |
| EXTEM LI60 (%) | 96.0 (91.4–100.7) | 84.1 (74.9–93.3) | 0.002 |
| EXTEM TPI | 24.1 (19.8–28.4) | 15.5 (11.8–19.2) | <0.001 |
| FIBTEM MCF (mm) | 5.0 (4.2–5.9) | 3.5 (2.6–4.4) | <0.001 |
| Prothrombin Time (sec) | 7.5 (7.3–7.7) | 8.5 (8.2–8.8) | <0.001 |
| Activated Partial Thromboplastin Time (sec) | 15.4 (14.8–16.0) | 14.4 (13.6–15.1) | <0.001 |
| Fibrinogen Concentration (g L−1) | 1.41 (1.29–1.54) | 0.97 (0.87–1.08) | <0.001 |
| Factor VII Activity (%) | 99.1 (92.5–105.7) | 77.8 (71.7–84.0) | <0.001 |
| Factor VIII Activity (%) | 109.8 (98.0–121.6) | 155.4 (139.9–171.0) | <0.001 |
| von Willebrand Factor Antigen (%) | 100.6 (90.0–111.3) | 74.3 (60.2–88.4) | <0.001 |
Paired t-test, bold indicates P < 0.05. α, alpha angle; CFT, clot formation time; CT, clotting time; LI60, lysis index at 60 min; MCF, maximum clot firmness; TPI, thrombodynamic potential index.
In the original article, there was an error. A conversion factor was inadvertently omitted from the equation for thrombodynamic potential index (TPI).
A correction has been made to Materials and Methods, Coagulation Parameters, Paragraph 3:
Rotational thromboelastometry (ROTEM® delta, Tem International GmbH) was performed according to the manufacturer's instructions and PROVETS guidelines (28) using the INTEM (star-TEM and in-TEM reagents), EXTEM (star-TEM and r ex-TEM reagents), FIBTEM (r ex-TEM and fib-TEM reagents), and APTEM (r ex-TEM and ap-TEM reagents) profiles. Measurement was started 30 min after sample collection. Each profile was run for at least 1 h following initiation. Data recorded for the INTEM and EXTEM profiles included clotting time (CT), clot formation time (CFT), alpha angle (α), maximum clot firmness (MCF), and lysis index at 60 min (LI60). Thrombodynamic potential index (TPI) was recorded for the EXTEM profile as a measure of global coagulation (29), calculated using the equations:
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.