Table 1.

Allocation and Disposition of Subjects

Test	Treatment	No. Entered	No. Used	No. Excluded and Reason

Von Frey and Cold^a	Vehicle	15	10	3 euthanized for tumor load before behavior was complete; 2 died after paclitaxel injection
Von Frey and Cold^a	NR	12	12

PEAP^a	Vehicle	15	8	As above, plus 2 euthanized for tumor load before PEAP could be conducted
PEAP^a	NR	12	12

Locomotor Activity^a,^b	Tumor Only	8	8
	Tumor + Pac/Vehicle	6	6
	Tumor + Pac/NR	9	7	2 excluded due to freezing behavior
	Naïve	8	8
	Naïve i.v. PAC	6	6
	Naïve i.v. KES	6	6

NOR^c	Naïve	8	7	1 rat did not fulfill test criteria
	MNU+PAC	7	5	2 rats did not meet test criteria
	MNU+KES	6	6
	MNU only (no tumor)	7	6	1 rat did not fulfill test criteria

Natural Progression^d	Vehicle	14	12	2 excluded; 1 for keratin cyst and 1 for benign tumor
Natural Progression^d	NR	14	14	2 excluded; 1 for keratin cyst and 1 for benign tumor

PAC Treatment of Tumors^e	Vehicle	16	13	1 excluded; very large tumor at start of study; 2 died after paclitaxel injection
PAC Treatment of Tumors^e	NR	12	12

IENF in Tumor Naive^f	Naïve	5	5
	PAC + Vehicle	5	5
	PAC + NR	5	5

IENF in Tumor Bearing^g	Naïve	7	7
	PAC + Vehicle	7	7
	PAC + NR	7	7

Common superscripts indicate the same cohorts of rats were used for these studies. For the studies of Ki67 expression, tumors were randomly chosen from rats in the treatment groups in the natural progression and the PAC + tumor growth experiments.