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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Pain. 2020 Aug;161(8):1906–1924. doi: 10.1097/j.pain.0000000000001884

Figure 11: Developing DYN interneurons do not modulate thermal sensitivity.

Figure 11:

A) Plot of paw withdrawal latencies (PWL) in response to noxious heat before and 20–25 min after CLZ administration. There was no significant interaction between genotype and drug (F(1, 57) = 1.48, p = 0.22; RM three-way ANOVA), suggesting that spinal DYN interneurons do not influence heat sensation. B) Similarly, measurements of the withdrawal thresholds in response to noxious cold revealed no significant interaction between genotype and drug (F(1,61) = 0.21, p = 0.65; RM three-way ANOVA), thereby arguing against a role of inhibitory DYN interneurons in regulating cold sensitivity.