Figure 3.

Main Monocyte-Macrophage Infiltration in COVID-19 Lung Samples

(A) Transcriptome deconvolution of lymphoid-myeloid populations from biopsies of COVID-19 and healthy lungs (p value: differentiation of groups by Pearson correlation along the first principal axis). Abbreviations: HD_lung, lung biopsy of healthy donor; Lung_COVID-19, lung biopsy of patient with COVID-19; MO, monocyte; M1, M1 macrophage; M2, M2 macrophage; IDC, immature dendritic cell; MDC, mature dendritic cells; LYB, B lymphocyte; LYT, T lymphocyte; BEC, primary bronchial epithelial cells.

(B–E) (B) Bar plot of correlations between genes (Pearson coefficients) and the lymphoid (purple) and myeloid (blue) deconvolution of COVID-19 lung biopsies as compared with those of healthy donors; (C) Single-cell expression (bronchoalveolar lavage fluid) dot plot of markers that were positively correlated to COVID-19, by patient of origin: HD, mild COVID-19, and severe COVID-19 (percent: percent of cells expressing each marker, expression level: color intensity); (D) UMAP representation of single-cell transcriptome (bronchoalveolar lavage fluid) expression data from HDs or patients with mild or severe COVID-19 for S100A11 and (E) FCER1G.