Table 3.
Summary of variation at the PRNP locus and part of its promoter in North American deer. 2 N = number alleles (2x number of individuals), S = number of segregating sites, Hd = haplotype diversity, k = average number of differences between alleles, Pi = nucleotide diversity, F(x) = frequency of amino acid residues thought to be associated with decreased susceptibility to CWD at positions 95, 96, 225, 103, and 20. Hybrid white-tailed X mule deer were excluded from this table.
| PRNP | Wtde-NE | Mule-NE | Key | Btde-CA | Btde-AK | Wtde-NY | Coues | Wtde-MN |
|---|---|---|---|---|---|---|---|---|
| 2 N | 406 | 274 | 30 | 22 | 20 | 14 | 70 | 30 |
| S | 8 | 9 | 2 | 4 | 0 | 3 | 6 | 6 |
| # alleles | 10 | 12 | 2 | 5 | 1 | 4 | 7 | 8 |
| Hd | 0.446 | 0.583 | 0.4 | 0.47 | 0 | 0.74 | 0.62 | 0.8 |
| k | 0.554 | 0.774 | 0.81 | 0.53 | 0 | 0.95 | 1.43 | 1050 |
| Pi | 0.0007 | 0.0010 | 0.001 | 0.0007 | 0 | 0.0012 | 0.0019 | 0.00195 |
| F(95H) | 0.02 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| F(96S) | 0.16 | 0 | 1.0 | 0 | 0 | 0.14 | 0 | 0.30 |
| F(225 F) | 0 | 0.047 | 0 | 0 | 0 | 0 | 0 | 0 |
| F(103 T) | 0 | 0 | 0 | 0 | 0 | 0 | 0.26 | 0 |
| F(20 G) | 0.014 | 0.078 | 0 | 0 | 0 | 0 | 0 | 0 |
| Promoter | ||||||||
| 2 N | 338 | 242 | 30 | 20 | 12 | 12 | 70 | 30 |
| S | 23 | 5 | 9 | 5 | 0 | 10 | 7 | 17 |
| # alleles | 22 | 7 | 6 | 5 | 1 | 5 | 7 | 10 |
| Hd | 0.835 | 0.360 | 0.691 | 0.663 | 0 | 0.803 | 0.499 | 0.885 |
| k | 2.69 | 0.39 | 3.78 | 1.006 | 0 | 3.667 | 0.617 | 4.52 |
| Pi | 0.0053 | 0.0008 | 0.0073 | 0.00198 | 0 | 0.0072 | 0.0012 | 0.0089 |
| 8-base indel copies | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4-base indel copies | 15 | 0 | 0 | 4 | 0 | 0 | 67 | 1 |