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. 2020 Sep 26;8(18):4151–4161. doi: 10.12998/wjcc.v8.i18.4151

Celiac disease and Sjögren’s syndrome: A case report and review of literature

Daniel Vasile Balaban 1, Ancuta Mihai 2, Alina Dima 3, Alina Popp 4,5,6, Mariana Jinga 7, Ciprian Jurcut 8
PMCID: PMC7520766  PMID: 33024773

Abstract

BACKGROUND

Celiac disease (CD) is a systemic, chronic immune-mediated disease triggered by gluten ingestion in genetically-susceptible individuals, with a prevalence of 1% worldwide. Sjogren's syndrome (SS) is also a systemic autoimmune disease, mainly characterized by ocular and oral sicca symptoms and signs. Sharing a common genetic background, CD and SS are known associated autoimmune diseases, but currently available guidelines are not reporting it.

CASE SUMMARY

We report the case of a 39-year-old woman, who was in the care of her rheumatologist for 2 years with SS. On routine follow-up she was found to have iron deficiency, without anemia. She had no gastrointestinal complaints and denied any obvious source of blood loss. IgA tissue transglutaminase antibodies were positive and endoscopy with duodenal biopsies revealed crypt hyperplasia and villous atrophy. A diagnosis of CD was set and gluten-free diet was recommended.

CONCLUSION

We present a review of existing data in the literature regarding the association of the two diseases, summarizing prevalence studies of CD in SS patients and the other way around. Screening recommendations and future research perspectives are also discussed, highlighting clinically relevant unanswered questions with respect to the association of CD with SS.

Keywords: Celiac disease, Sjögren syndrome, Prevalence, Autoimmunity, Screening, Antibodies, Case report

Core Tip: Celiac disease (CD) and Sjögren's syndrome (SS) are associated autoimmune diseases, sharing a common genetic background. Although there is some evidence supporting the association of the two diseases, currently available guidelines are not sufficiently reporting it. We herein report a case of a patient with SS who was diagnosed with CD and summarize existing data in the literature regarding the association of the two diseases and discuss future research topics that remain to be answered with regard to this association. To the best of our knowledge this is the first literature review regarding these two pathologies concomitance.

INTRODUCTION

Within the circle of related-autoimmune diseases, celiac disease (CD) and Sjögren’s syndrome (SS) come together with type 1 diabetes mellitus, autoimmune thyroid disease, and primary biliary cholangitis[1]. In fact, a major stake when diagnosing one of the above autoimmune diseases is screening for the other ones, especially in the presence of a suggestive clinical scenario.

SS is an autoimmune disease mainly characterized by ocular and oral sicca symptoms and signs, positivity for certain autoantibodies (anti-SS-A/Ro and anti-SS-B/La), and suggestive minor salivary gland biopsies. All these items were integrated in classifications criteria, the most recent being the 2016 American College of Rheumatology/European League Against Rheumatism SS’s Classification Criteria[2]. In the same paper, the importance of extraglandular manifestations was highlighted by increasing the target population to which the classification criteria can be applied.

Meanwhile, CD is a gluten-dependent, autoimmune enteropathy, affecting 1% of the population with a continuously rising incidence, mainly because of an increase of correct positive diagnosis[3]. In the last few decades the paradigm of CD’s clinical spectrum dramatically changed from the classical forms with diarrhea to atypical forms. Moreover, the importance of extraintestinal manifestations and of clinical associated conditions has been increasingly recognized[4-7]; hence, CD is now regarded as a chronic, systemic disease triggered by the ingestion of gluten in genetically susceptible individuals. Since the 1960s[8], several publications have been addressing the co-association between SS and CD – first with case reports[9-11], then small series and cohorts.

However, awareness among internal medicine specialists, rheumatologists, and gastroenterologists remains unsatisfactory and currently available guidelines are not reporting this association[2,12].

We herein present the case of a patient with SS who was diagnosed with CD, and summarize the existing data about the association of the two autoimmune disorders, with a focus on clinical application. To the best of our knowledge, this is the first literature review analyzing the existing data related to these two pathologies concomitance.

CASE PRESENTATION

Chief complaints

We report the case of a 39-year-old woman who was in the care of her rheumatologist after being diagnosed with primary SS. Her illness began two years before with bilateral knee arthralgia, debilitating fatigue, xerophthalmia and xerostomia. With positive antinuclear antibodies, anti-Ro [> 200 UI/mL (normal value < 15)] and anti-La [57.5 UI/mL (normal value < 15)] antibodies, positive Shirmer's test, positive Rose Bengal coloration, and salivary gland biopsy demonstrating focal lymphocytic sialadenitis with a focus score of 4, she was diagnosed with SS. She was prescribed hydroxychloroquine and topical treatment, with improvement of sicca and articular symptoms.

History of present illness

Two years later she came into the Rheumatology Department for a routine follow-up visit. She reported good symptom control with therapy without adverse reactions, and her physical examination was unremarkable.

Laboratory examinations

However, routine blood work however revealed lymphopenia-1100/mL (normal range 1170-3170), iron deficiency without anemia [serum iron–23 ug/dL (70-180), ferritin–18 μg/L (20-250), hemoglobin–12.9 g/dL (12-16)] and low vitamin D levels–10 ng/mL (20-160). Except regular menses, the patient's history did not reveal any obvious sources of blood loss. Upon further history taking, she did not report any digestive symptoms.

Further diagnostic work-up

Considering the autoimmune background and the suspicion of associated malabsorption syndrome, screening for CD was recommended. Blood was drawn for serum IgA and IgA tissue transglutaminase (tTG) antibodies. The diagnosis approach was completed with upper gastrointestinal endoscopy which showed mucosal fissures and scalloping in the distal duodenum, with multiple biopsies being taken both from the bulb and distal duodenum (Figure 1 A and B). The histopathology report revealed marked villous atrophy with crypt hyperplasia and intraepithelial lymphocytosis, corresponding to Marsh 3c classification (Figure 2). IgA tissue transglutaminase antibody levels were over 200U (Quanta Lite® h-tTG IgA/Inova, cut-off positivity 20 U).

Figure 1.

Figure 1

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Endoscopic images showing mucosal fissures and scalloping in the distal duodenum.

Figure 2.

Figure 2

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Hematoxilin-eosin stain of duodenal biopsy sample showing marked villous atrophy with crypt hyperplasia and intraepithelial lymphocytosis, corresponding to Marsh 3c classification.

FINAL DIAGNOSIS

Thus, a diagnosis of CD was made.

TREATMENT

Nutritional therapy, consisting of a gluten-free diet, was recommended.

OUTCOME AND FOLLOW-UP

Upon follow-up, serum iron and ferritin levels normalized, IgA tTG gradually decreased to negative titers and control biopsy revealed restoring of normal villous architecture but with persisting intraepithelial lymphocytosis (Figure 3).

Figure 3.

Figure 3

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Hematoxilin-eosin stain of follow-up biopsy revealing restoring of normal villous architecture but with persisting intraepithelial lymphocytosis.

DISCUSSION

In our case presentation, we report a diagnosis of CD in a patient with SS, without any gastrointestinal complaints, starting from mild laboratory changes during a routine follow-up visit. Notably, the subtle alterations in the blood work-up along with a high index of suspicion of the clinician triggered CD testing.

Although the association of CD and SS is well recognized, awareness among practitioners of related medical specialties is far from being satisfactory[13], so opportunities to diagnose CD/SS are often missed. Both disorders are known to be significantly underdiagnosed and this exposes patients to complications and impaired quality of life[14,15]. In this setting, searching for CD in SS patients and vice versa could represent an important case-finding tool.

Prevalence of CD in patients with SS

Several papers have looked at the frequency of CD in SS patients. The prevalence of CD among patients with SS ranges from 1% to 14.7% (Iltanen et al[16]) – as noted in Table 1[16-22], while the prevalence of CD in general population is about 1%. However, existing data in the literature has important limitations – the studies performed in cohorts of patients with SS included a limited number of patients and the diagnostic criteria used were not similar. The Finnish series by Iltanen et al[16] comprised a small number of patients (34 SS) and reported a high prevalence of 14.7% CD in patients with SS. All five CD patients had atrophic mucosal injury in the biopsy samples, with recovery on a gluten-free diet, while on serology, they were positive for either IgA-antiendomysial antibodies (EMA) or the old generation IgA antigliadin antibodies (AGA); the authors acknowledged the low specificity of IgA-AGA as serological screening in SS. As in our case, the clinical picture of CD patients diagnosed by screening was not prominent, and two of them had nutritional deficiencies (iron and folic acid deficiency, respectively). Of note, four SS non-CD patients had normal villous architecture with an increased density of intraepithelial γδ T cells, while two of them were also positive for HLA DQ2, which could represent CD latency. A rather high seroprevalence (12%) was also reported in a small cohort of SS patients (n = 50) in the study by Luft et al[20], five out of the six positive being biopsy-confirmed CD (10%); the authors also found that prevalence of tTG was higher in SS as compared with other rheumatic diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis or systemic sclerosis. On the other hand, Fasano et al[22] reported a low prevalence, of 2%, in a cohort of 98 SS patients, and so did Bizzaro et al[19], who found a seroprevalence similar to the one in the general population, of 1%: The one patient in a cohort of 100 SS was IgG tTG positive, but IgA and IgG EMA were negative, as was HLA typing, and according to study protocol, was not biopsied. Other studies such as the one by Caio et al[21] also reported on serology only, lacking histological confirmation; in their study, there was also a SS case with isolated, low titer, IgG anti-deamidated gliadin peptide antibodies (DGP) positivity, which could raise the CD prevalence to 7.7% if histologically-confirmed. In the largest cohort published, Bartoloni et al[18] reported a prevalence of 7.1% biopsy- proven CD, with 24 out of the 25 confirmed cases being previously diagnosed with CD; screening detected only one additional subclinical CD. The major issue of the aforementioned studies reporting on prevalence of CD in SS is the heterogeneity of criteria used for CD diagnosis, which partly explains the wide range of prevalence rates. However, when summarizing available data, there seems to be a higher prevalence of CD in SS patients than in general population. Although other larger studies have reported strong associations of SS with other CD-related autoimmune diseases such as ATD or PBC, CD was not looked for in these cohorts[23,24]. We hypothesize that overlooking CD in a patient with SS might be due to the gastrointestinal involvement secondary to SS itself, which would be labelled as a disease manifestation and would not trigger testing for CD.

Table 1.

Summary of studies reporting prevalence of celiac disease in Sjogren syndrome

Ref. SS (n) Country CD prevalence (SS + CD) Serological criteria Histological criteria
Iltanen et al[16] 34 SS+, 28 controls Finland 14.7% (n = 5) SS+ CD; 3/5 IgA EMA+; 4/5 IgA AGA+; 5/5 IgA EMA or AGA +; SS – CD; 0/28 IgA EMA +; 9/28 IgA AGA + All 5 seropositive - Marsh 3
Szodoray et al[17] 111 SS+ Hungary 4.5% (n =5 ) 6/111 tTG and/or AGA and/or EMA + 5/6 CD+, one with jejunitis
Bartoloni et al[18] 354 SS+, 14298 controls Italy 7.1% (n = 25), 6.8% (n = 24) previously diagnosed CD, 1 latent CD 24 previously diagnosed (2013 WGO guideline criteria), 1 IgA tTG+ All 25
Bizzaro et al[19] 100 SS+ Italy, Israel 1% (n = 1) 1 IgG tTG + (IgA tTG-) Histology not done
Luft et al[20] 50 SS+, 50 controls 40 disease-controls (CD+) Canada 12% (n = 6) 6 IgA tTG + 5/6 biopsy-proven CD
Caio et al[21] 52 SS+ Italy 5.8% (n = 3) 3/42 IgA tTG+, IgG DGP + and IgA EMA+ Histology not used
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SS: Sjogren syndrome; CD: Celiac disease; AGA: Anti-gliadin antibodies; EMA: Antiendomysial antibodies.

Prevalence of SS in patients with CD

Conversely, other authors have also looked at the SS occurrence in CD patients, results of which are summarized in Table 2[25-29]. Using the California criteria for SS, Collin et al[28] reported a prevalence of 3.3% for SS in patients with CD, a significant association in contrast with other connective tissue disease[28], while Caglar et al[27] reported a prevalence of 6.5% (SS-A/SS-B antibody)[27]. Ayar et al[29] found a high frequency of dry eye/mouth in CD patients, with approximately one in four being symptomatic, but only few had a biopsy-based diagnosis of SS; the frequency of SS classified according to the 2012 ACR or to American-European Consensus Group criteria was 4.9%[29]. Similarly, in a small cohort of 82 CD patients, Erbasan et al[25] reported a high prevalence of dry eye (29.3%) and dry mouth (24.4%) symptoms; in this group, the diagnosis of SS was proven by biopsy in 1.2% of CD patients[25]. Moreover, four patients (4.9%) were diagnosed with undifferentiated connective tissue disease, two of them being positive for anti-SS-A/La antibodies, but having though negative biopsies. As for the studies analyzing CD prevalence in SS, the ones looking at SS prevalence in patients with CD are also very heterogeneous with respect to diagnostic criteria.

Table 2.

Summary of studies reporting prevalence of Sjogren syndrome in celiac disease

Ref. CD (n) Country SS prevalence (SS + CD) Diagnostic criteria
Erbasan et al[25] 82 Turkey 1.2% 29.3% dry eye, 24.4% dry mouth; 14.6% ANA+
Bibbò et al[26] 255 Italy 2.4%
Caglar et al[27] 31 Turkey 6.5% 12.9% ANA+; 6.5% SS-A/Ro+ and/or SS-B/La+
Collin et al[28] 335 Finland 3.3%
Ayar et al[29] 81 Turkey 4.9% 23.5% dry eye, 27.2% dry mouth
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SS: Sjogren syndrome; CD: Celiac disease; ANA: Antinuclear antibodies.

Even if symptomatology like dry mouth or eye is frequently reported in CD patients, biopsy in search for SS is only rarely assessed. Therefore, the available data are incomplete. Even so, the concomitance of SS and CD seems not to be random.

In summary, there is scarce data on SS prevalence in CD, and from the available publications, there is a lack of uniformity with respect to specific classification criteria, study design, and population examined.

Pathophysiology and antibodies in CD and SS

The antibody spectrum in CD and SS has been looked at in a few studies. On one hand, there is data supporting a high prevalence of antinuclear antibodies in patients with CD, ranging from 8.9% (da Rosa Utiyama et al[30]) to 14.6% (Erbasan et al[25]). Additionally, the anti-SS-A/Ro and anti-SS-B/La antibodies were reported to have a prevalence of 6.5% in 31 patients with CD[27]. On the other hand, earlier studies using gliadin-based serology have shown significant positivity of CD-related antibodies in SS: Teppo et al[31] found higher values of gliadin, gluten and reticulin antibodies in SS patients compared to rheumatoid arthritis or SLE. Significant false positivity of native AGA has also been reported also in other autoimmune diseases, such as SLE[32,33]. A study searching for immune and autoimmune gluten-related phenomenon in SLE patients found higher prevalence for tTG IgA and DGP (3.4% and 4.7%, respectively), but similar to general population prevalence for EMA (0.8%). Moreover, the tTG-IgA were found to be correlated with leucocytes, lymphocytes as well as with the complement levels[33].

To overcome the limitation of gliadin-based serology, clinicians should remember that EMA has the highest specificity for diagnosing CD, and IgA-tTG remains the best test for initial screening with very high sensitivity and specificity[34,35].

The association between CD and SS-related autoantibodies might be based on common genetic background of these two pathologies, related to DR3-DQ2 heterodimer coded by the DQA1*0501 and DQB1*0201 alleles[36,37]. Patients possessing these genetic markers had extractable nuclear antigen antibodies, and especially SS-B/La antibodies more frequent than patients negative for these alleles[38]. Moreover, it is well recognized that CD is associated with specific HLA types in virtually all populations that have been tested, and this very high negative predictive value of HLA-DQ2/DQ8 genotyping can be used to effectively rule out the disease in selected clinical situations[22,39]. For SS, the most relevant HLA genes involved in susceptibility are DR3–DQ2, with alleles DRB1*03:01, DQA1*05:01, and DQB1*02:01 being risk factors while, DQA1*03:01, DQA1*05:01 and DQB1*05:01 alleles were found to be protective factors[40].

Besides this common immunogenetic background, the link between SS and CD is also supported by studies researching gluten-challenge and gluten-free diet in SS patients. Therefore, the study by Patinen at al[41] showed improvement in terms of the autoimmune inflammatory process in the salivary glands of SS patients who were on a gluten-free diet because they had associated CD, while Lidén et al[42] revealed rectal mucosal inflammation in response to gluten challenge in SS patients, thus proving gluten-sensitivity of these patients. Not least, dermatitis herpetiformis, as a cutaneous equivalent of CD, has also been reported in SS[43].

Additionally, the histopathologic exam shows lymphocytes infiltrates in both SS and CD, namely a focal lymphocytic sialadenitis, with a focus score of ≥ 1 foci/4 mm2 in SS accordingly to the 2016 ACR/ EULAR SS’s classification criteria[2], and intraepithelial lymphocytic infiltration, more than 25 lymphocytes/100 epithelial cell, with associated villous and crypt architectural changes, in CD[12].

Moreover, both SS and CD pathologies are associated with an increased risk of lymphoma occurrence. Initially considered a T cell dysregulation, we recognized that the major derangement and dysregulation of the B lymphocytes in both peripheral circulation and glandular tissues of the SS patients plays a central part in the pathogenic processes[44]. The lymphoma risk is increased in SS patients especially for the marginal zone lymphoma, namely the parotid gland mucosa associated lymphoid tissue lymphoma, and the diffuse large B-cell lymphoma[45]. In CD, particularly patients with refractory CD, defined as persistent clinical and histological changes after at least 12 months of sustained gluten-free diet, especially in cases with monoclonal rearrangement of T cell receptor (type 2), occurrence of intestinal lymphoma might complicate the clinical course. The risk of both B and T cell lymphoma is increased in CD, and is the highest for the non-Hodgkin T cell intestinal lymphoma (six to nine times higher than in general population)[46].

Screening recommendations and future direction

Despite the strong association between the two conditions, currently available guidelines fail to recommend screening for SS in CD patients and vice versa[2,12], except the 2009 National Institute for Health and Clinical Excellence guideline that recommended that patients with SS may be considered for CD testing[47]. However, the updated and most recent NICE guideline on CD does not recommend screening for CD in patients with SS[48]. Similarly, the 2017 United States Preventive Services Task Force does not include the SS in the target group for the CD screening[49].

Although data in the literature is not as large as for other associated autoimmune diseases such as type 1 DM or ATD disease[6,50], testing for CD should be thought of in a symptomatic SS patient or upon detection of isolated iron deficiency, alterations of liver functions tests or pancreatic enzymes. However, there are some authors who recommend routine CD screening in patients with SS[51]; this would be readily available by IgA tTG testing, which has become increasingly accessible and improved significantly over the last years in terms of standardization of the kits used[52]. It is important to remember that IgA deficiency is more frequently found in CD patients, therefore the serum IgA level should also be tested, and IgG-based serology should be done in cases with IgA deficiency[53]. In this population of IgA-deficient individuals, DGP testing has been proven to be an accurate tool to identify CD[54]. Nevertheless, one should keep in mind the possibility of seronegative CD, meaning villous atrophy (VA) with negative CD-serology, when diagnosis can be supported by celiac-type mucosal injury on histopathology, exclusion of other causes of VA, along with HLA typing and response to gluten-free diet[55-57].

Thus, there are some clinical scenarios needing the search of CD in SS patients or SS in CD patients in Table 3[23]. Further studies should focus on indications, screening methods, timing of screening and frequency of testing for SS in CD patients and vice versa in Table 4.

Table 3.

Clinical scenarios needing the search of celiac disease in Sjögren syndrome patients or Sjögren syndrome in celiac disease patients

When to consider CD in SS patients?
 When to consider SS in CD patients?
Suggestive gastrointestinal symptoms; Suspected malabsorption; Hypogammaglobulinemia and low levels of total protein; High levels of transaminases without evident cause; Anemia of unknown cause; Herpetiform dermatitis; Autoimmune thyroiditis (frequent in SS patients)[47]1 Dry eyes and dry mouth symptoms; Enlarged parotid glands; Hypergammaglobulinemia and high levels of total protein; Polyneuropathy; Arthritis (arthralgias?); Purpura
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1

The National Institute for Health and Clinical Excellence guideline recommends that all patients with autoimmune thyroid disease must be screened for celiac disease. CD: Celiac disease; SS: Sjögren syndrome.

Table 4.

Future agenda

Describing the prevalence of SS in patients with CD using the new classification criteria for SS
Describing the prevalence of CD in SS patients using newer generation serology tests
Prospective studies in patients with both conditions regarding evolution and prognosis, especially regarding the possible additive risk of lymphoma
Describing the role of gluten free diet regarding SS symptoms in patients associating both diseases
Developing clear recommendations for screening for SS in CD and for CD in SS
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CD: Celiac disease; SS: Sjögren syndrome.

Moreover, another important question that is yet to be answered is about the role of gluten-free diet in non-CD, SS patients. Several papers have reported benefits of the gluten free diet in various non-celiac autoimmune diseases, but results remain controversial[58,59]. Considering all the drawbacks of a gluten-free diet in the absence of gluten-intolerance, the role of gluten-free diet in SS remains to be studied and cannot be recommended yet on the basis of current evidence.

CONCLUSION

Sharing also a common genetic background, CD and SS are found to be associated, but evidence to quantify the magnitude of this association is lacking. This concomitance of these two diseases is however easily overlooked in clinical practice and currently available guidelines fail to recognize it. Further research should look at indications for screening, testing methods, as well as the role of the gluten-free diet in non-CD SS patients.

ACKNOWLEDGEMENTS

We would like to thank Dr. Vasilescu Florina for her support with the histology slides.

Footnotes

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Manuscript source: Invited manuscript

Peer-review started: February 27, 2020

First decision: April 8, 2020

Article in press: August 25, 2020

Specialty type: Medicine, research and experimental

Country/Territory of origin: Romania

Peer-review report’s scientific quality classification

Grade A (Excellent): A

Grade B (Very good): B

Grade C (Good): 0

Grade D (Fair): D, D

Grade E (Poor): E

P-Reviewer: Iovino P, Kansu A, Kaya M, Ribaldone DG, Vasudevan A S-Editor: Zhang L L-Editor: A P-Editor: Wang LL

Contributor Information

Daniel Vasile Balaban, Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Dr. Carol Davila Central Military Emergency University Hospital, Bucharest 020021, Romania.

Ancuta Mihai, Internal Medicine, Dr. Carol Davila Central Military Emergency University Hospital, Bucharest 010825, Romania.

Alina Dima, Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Dr. Carol Davila Central Military Emergency University Hospital, Bucharest 020021, Romania.

Alina Popp, Pediatrics, Carol Davila University of Medicine and PharmacyCarol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania; Alfred Rusescu Institute for Mother and Child Care, Bucharest 020021, Romania; Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Bucharest 020021, Romania.

Mariana Jinga, Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Dr. Carol Davila Central Military Emergency University Hospital, Bucharest 020021, Romania. mariana_jinga@yahoo.com.

Ciprian Jurcut, Internal Medicine, Dr. Carol Davila Central Military Emergency University Hospital, Bucharest 010825, Romania.

References

  • 1.Lauret E, Rodrigo L. Celiac disease and autoimmune-associated conditions. Biomed Res Int. 2013;2013:127589. doi: 10.1155/2013/127589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ, Mariette X International Sjögren's Syndrome Criteria Working Group. 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts. Arthritis Rheumatol. 2017;69:35–45. doi: 10.1002/art.39859. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Ludvigsson JF, Murray JA. Epidemiology of Celiac Disease. Gastroenterol Clin North Am. 2019;48:1–18. doi: 10.1016/j.gtc.2018.09.004. [DOI] [PubMed] [Google Scholar]
  • 4.Ribaldone DG, Astegiano M, Fagoonee S, Rizzetto M, Pellicano R. Epilepsy and celiac disease: review of literature. Panminerva Med. 2011;53:213–216. [PubMed] [Google Scholar]
  • 5.Ciaccio EJ, Lewis SK, Biviano AB, Iyer V, Garan H, Green PH. Cardiovascular involvement in celiac disease. World J Cardiol. 2017;9:652–666. doi: 10.4330/wjc.v9.i8.652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Freeman HJ. Endocrine manifestations in celiac disease. World J Gastroenterol. 2016;22:8472–8479. doi: 10.3748/wjg.v22.i38.8472. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7.Dima A, Jurcut C, Jinga M. Rheumatologic manifestations in celiac disease: what should we remember? Rom J Intern Med. 2019;57:3–5. doi: 10.2478/rjim-2018-0024. [DOI] [PubMed] [Google Scholar]
  • 8.Pittman FE, Holub DA. Sjoegren's syndrome and adult celiac disease. Gastroenterology. 1965;48:869–876. [PubMed] [Google Scholar]
  • 9.Peña AS. Systemic lupus erythematosus, Sjögren's syndrome, and purpura in a patient with coeliac disease. Neth J Med. 1987;31:305–307. [PubMed] [Google Scholar]
  • 10.Maclaurin BP, Matthews N, Kilpatrick JA. Coeliac disease associated with auto-immune thyroiditis, Sjogren's syndrome, and a lymphocytotoxic serum factor. Aust N Z J Med. 1972;2:405–411. doi: 10.1111/j.1445-5994.1972.tb03946.x. [DOI] [PubMed] [Google Scholar]
  • 11.Lancaster-Smith MJ, Strickland ID. Autoantibodies in adult coeliac disease. Lancet. 1971;1:1244. doi: 10.1016/s0140-6736(71)91761-2. [DOI] [PubMed] [Google Scholar]
  • 12.Al-Toma A, Volta U, Auricchio R, Castillejo G, Sanders DS, Cellier C, Mulder CJ, Lundin KEA. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019;7:583–613. doi: 10.1177/2050640619844125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Jinga M, Popp A, Balaban DV, Dima A, Jurcut C. Physicians' attitude and perception regarding celiac disease: A questionnaire-based study. Turk J Gastroenterol. 2018;29:419–426. doi: 10.5152/tjg.2018.17236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14.Laurikka P, Nurminen S, Kivelä L, Kurppa K. Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes. Nutrients. 2018;10 doi: 10.3390/nu10081015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15.Violato M, Gray A. The impact of diagnosis on health-related quality of life in people with coeliac disease: a UK population-based longitudinal perspective. BMC Gastroenterol. 2019;19:68. doi: 10.1186/s12876-019-0980-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Iltanen S, Collin P, Korpela M, Holm K, Partanen J, Polvi A, Mäki M. Celiac disease and markers of celiac disease latency in patients with primary Sjögren's syndrome. Am J Gastroenterol. 1999;94:1042–1046. doi: 10.1111/j.1572-0241.1999.01011.x. [DOI] [PubMed] [Google Scholar]
  • 17.Szodoray P, Barta Z, Lakos G, Szakáll S, Zeher M. Coeliac disease in Sjögren's syndrome--a study of 111 Hungarian patients. Rheumatol Int. 2004;24:278–282. doi: 10.1007/s00296-003-0360-x. [DOI] [PubMed] [Google Scholar]
  • 18.Bartoloni E, Bistoni O, Alunno A, Cavagna L, Nalotto L, Baldini C, Priori R, Fischetti C, Fredi M, Quartuccio L, Carubbi F, Montecucco C, Doria A, Mosca M, Valesini G, Franceschini F, De Vita S, Giacomelli R, Mirabelli G, Bini V, Gabrielli A, Catassi C, Gerli R. Celiac Disease Prevalence is Increased in Primary Sjögren's Syndrome and Diffuse Systemic Sclerosis: Lessons from a Large Multi-Center Study. J Clin Med. 2019;8 doi: 10.3390/jcm8040540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Bizzaro N, Villalta D, Tonutti E, Doria A, Tampoia M, Bassetti D, Tozzoli R. IgA and IgG tissue transglutaminase antibody prevalence and clinical significance in connective tissue diseases, inflammatory bowel disease, and primary biliary cirrhosis. Dig Dis Sci. 2003;48:2360–2365. doi: 10.1023/b:ddas.0000007875.72256.e8. [DOI] [PubMed] [Google Scholar]
  • 20.Luft LM, Barr SG, Martin LO, Chan EK, Fritzler MJ. Autoantibodies to tissue transglutaminase in Sjögren's syndrome and related rheumatic diseases. J Rheumatol. 2003;30:2613–2619. [PubMed] [Google Scholar]
  • 21.Caio G, De Giorgio R, Ursini F, Fanaro S, Volta U. Prevalence of celiac disease serological markers in a cohort of Italian rheumatological patients. Gastroenterol Hepatol Bed Bench. 2018;11:244–249. [PMC free article] [PubMed] [Google Scholar]
  • 22.Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, Elitsur Y, Green PH, Guandalini S, Hill ID, Pietzak M, Ventura A, Thorpe M, Kryszak D, Fornaroli F, Wasserman SS, Murray JA, Horvath K. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med. 2003;163:286–292. doi: 10.1001/archinte.163.3.286. [DOI] [PubMed] [Google Scholar]
  • 23.Baldini C, Ferro F, Mosca M, Fallahi P, Antonelli A. The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders. Front Endocrinol (Lausanne) 2018;9:121. doi: 10.3389/fendo.2018.00121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 24.Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med. 2004;164:1275–1284. doi: 10.1001/archinte.164.12.1275. [DOI] [PubMed] [Google Scholar]
  • 25.Erbasan F, Çoban DT, Karasu U, Çekin Y, Yeşil B, Çekin AH, Süren D, Terzioğlu ME. Primary Sjögren's syndrome in patients with celiac disease. Turk J Med Sci. 2017;47:430–434. doi: 10.3906/sag-1601-149. [DOI] [PubMed] [Google Scholar]
  • 26.Bibbò S, Pes GM, Usai-Satta P, Salis R, Soro S, Quarta Colosso BM, Dore MP. Chronic autoimmune disorders are increased in coeliac disease: A case-control study. Medicine (Baltimore) 2017;96:e8562. doi: 10.1097/MD.0000000000008562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27.Caglar E, Ugurlu S, Ozenoglu A, Can G, Kadioglu P, Dobrucali A. Autoantibody frequency in celiac disease. Clinics (Sao Paulo) 2009;64:1195–1200. doi: 10.1590/S1807-59322009001200009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Collin P, Reunala T, Pukkala E, Laippala P, Keyriläinen O, Pasternack A. Coeliac disease--associated disorders and survival. Gut. 1994;35:1215–1218. doi: 10.1136/gut.35.9.1215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Ayar K, Tunз R, Pekel H, Kьзьk A, Esen HH, Çifзi S, Ataseven H. The frequency of Sjogren’s syndrome in celiac patients; a cross-sectional controlled clinical trial. Ann Rheum Dis. 2015;74:1094–1095. [Google Scholar]
  • 30.da Rosa Utiyama SR, da Silva Kotze LM, Nisihara RM, Carvalho RF, de Carvalho EG, de Sena MG, de Messias Reason IJ. Spectrum of autoantibodies in celiac patients and relatives. Dig Dis Sci. 2001;46:2624–2630. doi: 10.1023/a:1012702807714. [DOI] [PubMed] [Google Scholar]
  • 31.Teppo AM, Maury CP. Antibodies to gliadin, gluten and reticulin glycoprotein in rheumatic diseases: elevated levels in Sjögren's syndrome. Clin Exp Immunol. 1984;57:73–78. [PMC free article] [PubMed] [Google Scholar]
  • 32.Rensch MJ, Szyjkowski R, Shaffer RT, Fink S, Kopecky C, Grissmer L, Enzenhauer R, Kadakia S. The prevalence of celiac disease autoantibodies in patients with systemic lupus erythematosus. Am J Gastroenterol. 2001;96:1113–1115. doi: 10.1111/j.1572-0241.2001.03753.x. [DOI] [PubMed] [Google Scholar]
  • 33.Dima A, Jurcut C, Balanescu E, Badea C, Lacatus N, Popp A. Immune and autoimmune gluten-related phenomenon in systemic lupus erythematosus. Lupus. 2017;26:1235–1236. doi: 10.1177/0961203317700483. [DOI] [PubMed] [Google Scholar]
  • 34.Schyum AC, Rumessen JJ. Serological testing for celiac disease in adults. United European Gastroenterol J. 2013;1:319–325. doi: 10.1177/2050640613502788. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Chou R, Bougatsos C, Blazina I, Mackey K, Grusing S, Selph S. Screening for Celiac Disease: Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2017;317:1258–1268. doi: 10.1001/jama.2016.10395. [DOI] [PubMed] [Google Scholar]
  • 36.Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology. 1993;105:910–922. doi: 10.1016/0016-5085(93)90912-v. [DOI] [PubMed] [Google Scholar]
  • 37.Kang HI, Fei HM, Saito I, Sawada S, Chen SL, Yi D, Chan E, Peebles C, Bugawan TL, Erlich HA. Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjögren's syndrome. J Immunol. 1993;150:3615–3623. [PubMed] [Google Scholar]
  • 38.D'Onofrio F, Miele L, Diaco M, Santoro L, De Socio G, Montalto M, Grieco A, Gasbarrini G, Manna R. Sjogren's syndrome in a celiac patient: searching for environmental triggers. Int J Immunopathol Pharmacol. 2006;19:445–448. doi: 10.1177/039463200601900222. [DOI] [PubMed] [Google Scholar]
  • 39.Ludvigsson JF, Bai JC, Biagi F, Card TR, Ciacci C, Ciclitira PJ, Green PH, Hadjivassiliou M, Holdoway A, van Heel DA, Kaukinen K, Leffler DA, Leonard JN, Lundin KE, McGough N, Davidson M, Murray JA, Swift GL, Walker MM, Zingone F, Sanders DS BSG Coeliac Disease Guidelines Development Group; British Society of Gastroenterology. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut. 2014;63:1210–1228. doi: 10.1136/gutjnl-2013-306578. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40.Cruz-Tapias P, Rojas-Villarraga A, Maier-Moore S, Anaya JM. HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies. Autoimmun Rev. 2012;11:281–287. doi: 10.1016/j.autrev.2011.10.002. [DOI] [PubMed] [Google Scholar]
  • 41.Patinen P, Aine L, Collin P, Hietanen J, Korpela M, Enckell G, Kautiainen H, Konttinen YT, Reunala T. Oral findings in coeliac disease and Sjögren's syndrome. Oral Dis. 2004;10:330–334. doi: 10.1111/j.1601-0825.2004.01048.x. [DOI] [PubMed] [Google Scholar]
  • 42.Lidén M, Kristjánsson G, Valtýsdóttir S, Hällgren R. Gluten sensitivity in patients with primary Sjögren's syndrome. Scand J Gastroenterol. 2007;42:962–967. doi: 10.1080/00365520701195345. [DOI] [PubMed] [Google Scholar]
  • 43.Fraser NG, Rennie AG, Donald D. Dermatitis herpetiformis and Sjögren's syndrome. Br J Dermatol. 1979;100:213–215. doi: 10.1111/j.1365-2133.1979.tb05563.x. [DOI] [PubMed] [Google Scholar]
  • 44.Ibrahem HM. B cell dysregulation in primary Sjögren's syndrome: A review. Jpn Dent Sci Rev. 2019;55:139–144. doi: 10.1016/j.jdsr.2019.09.006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 45.Gorodetskiy VR, Probatova NA, Radenska-Lopovok SG, Ryzhikova NV, Sidorova YV, Sudarikov AB. Clonal relationship of marginal zone lymphoma and diffuse large B-cell lymphoma in Sjogren's syndrome patients: case series study and review of the literature. Rheumatol Int. 2020;40:499–506. doi: 10.1007/s00296-019-04470-x. [DOI] [PubMed] [Google Scholar]
  • 46.Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, Fasano A. Celiac disease: a comprehensive current review. BMC Med. 2019;17:142. doi: 10.1186/s12916-019-1380-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47.Centre for Clinical Practice at NICE (UK) Coeliac Disease: Recognition and Assessment of Coeliac Disease [Internet] London: National Institute for Health and Clinical Excellence (UK); 2009. [PubMed] [Google Scholar]
  • 48.Internal Clinical Guidelines Team (UK) Coeliac Disease: Recognition, Assessment and Management. London: National Institute for Health and Care Excellence (UK); 2015. [PubMed] [Google Scholar]
  • 49.US Preventive Services Task Force. Bibbins-Domingo K, Grossman DC, Curry SJ, Barry MJ, Davidson KW, Doubeni CA, Ebell M, Epling JW Jr, Herzstein J, Kemper AR, Krist AH, Kurth AE, Landefeld CS, Mangione CM, Phipps MG, Silverstein M, Simon MA, Tseng CW. Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement. JAMA. 2017;317:1252–1257. doi: 10.1001/jama.2017.1462. [DOI] [PubMed] [Google Scholar]
  • 50.Akirov A, Pinhas-Hamiel O. Co-occurrence of type 1 diabetes mellitus and celiac disease. World J Diabetes. 2015;6:707–714. doi: 10.4239/wjd.v6.i5.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 51.Roblin X, Helluwaert F, Bonaz B. Celiac disease must be evaluated in patients with Sjögren syndrome. Arch Intern Med. 2004;164:2387. doi: 10.1001/archinte.164.21.2387. [DOI] [PubMed] [Google Scholar]
  • 52.Stern M Working Group on Serologic Screening for Celiac Disease. Comparative evaluation of serologic tests for celiac disease: a European initiative toward standardization. J Pediatr Gastroenterol Nutr. 2000;31:513–519. doi: 10.1097/00005176-200011000-00012. [DOI] [PubMed] [Google Scholar]
  • 53.Balaban DV, Popp A, Ionita Radu F, Jinga M. Hematologic Manifestations in Celiac Disease-A Practical Review. Medicina (Kaunas) 2019;55 doi: 10.3390/medicina55070373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 54.Leffler DA, Schuppan D. Update on serologic testing in celiac disease. Am J Gastroenterol. 2010;105:2520–2524. doi: 10.1038/ajg.2010.276. [DOI] [PubMed] [Google Scholar]
  • 55.Aziz I, Peerally MF, Barnes JH, Kandasamy V, Whiteley JC, Partridge D, Vergani P, Cross SS, Green PH, Sanders DS. The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015) Gut. 2017;66:1563–1572. doi: 10.1136/gutjnl-2016-312271. [DOI] [PubMed] [Google Scholar]
  • 56.Volta U, Caio G, Boschetti E, Giancola F, Rhoden KJ, Ruggeri E, Paterini P, De Giorgio R. Seronegative celiac disease: Shedding light on an obscure clinical entity. Dig Liver Dis. 2016;48:1018–1022. doi: 10.1016/j.dld.2016.05.024. [DOI] [PubMed] [Google Scholar]
  • 57.DeGaetani M, Tennyson CA, Lebwohl B, Lewis SK, Abu Daya H, Arguelles-Grande C, Bhagat G, Green PH. Villous atrophy and negative celiac serology: a diagnostic and therapeutic dilemma. Am J Gastroenterol. 2013;108:647–653. doi: 10.1038/ajg.2013.45. [DOI] [PubMed] [Google Scholar]
  • 58.Lerner A, Ramesh A, Matthias T. Going gluten free in non-celiac autoimmune diseases: the missing ingredient. Expert Rev Clin Immunol. 2018;14:873–875. doi: 10.1080/1744666X.2018.1524757. [DOI] [PubMed] [Google Scholar]
  • 59.Lerner A, Ramesh A, Matthias T. Are Non-Celiac Autoimmune Diseases Responsive to Gluten-Free Diet? Int J Celiac Dis. 2017;5:164–167. [Google Scholar]

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