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. 2020 May 21;23(4):581–597. doi: 10.1007/s10456-020-09727-9

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Fig. 5 — Comparison of normal and tumor ECs from different host organs revealed tissue-specific signatures in ECs. a t-SNE plot of a collection of ECs from different normal tissues (liver in this study n = 719, heart n = 629, lung n = 401 and kidney n = 386) as well as tumors (intrahepatic tumors in this study and s.c. tumors n = 240). ECs are colored by clusters (left) or by tissue of origin and tumor types (right). b Heatmap showing top 10 cluster-enriched genes in different subpopulations (as in 5a). Gene signatures distinctive to tumor ECs are highlighted by dashed boxes. c Functions enriched in genes preferentially expressed by intrahepatic HT-29 tumor ECs compared to s.c. HT-29 tumor ECs. d Violin plots showing conserved tumor EC genes (Aplnr and Kcne3) with similar expression levels in intrahepatic and s.c. HT29 tumors and genes exclusively expressed in intrahepatic HT-29 tumor ECs (Tgfb1, Sumo2, Hras, Sox17)