Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 30;9:e59754. doi: 10.7554/eLife.59754

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020, Savier et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

Figure 4. — (A) Violin plot representation of the median IDIs (from n = 10 simulated maps, each composed of 100 projections) in WT, Isl2-Epha3KI and Isl2-Efna3KI animal models. Mann-Whitney test: WT IDI_retino vs. Isl2^Epha3/+ IDI_retino, z-score = 12.08, effect r = 0.85, p=6E-55; WT IDI_cortico vs. Isl2^Epha3/+ IDI_cortico, z-score = 12.04, effect r = 0.85, p=8E-52; Isl2^Epha3/+ IDI_retino vs Isl2^Epha3/Epha3 IDI_retino, z-score = 11.25, effect r = 0.80, p=2E-39; Isl2^Epha3/+ IDI_cortico vs Isl2^Epha3/Epha3 IDI_cortico, z-score = 10.53, effect r = 0.74, p=1E-32; WT IDI_cortico vs Isl2^Efna3/+ IDI_cortico, z-score = 8.30, effect r = 0.59, p=1E-18; WT IDI_cortico vs Isl2^Efna3/Efna3 IDI_cortico, z-score = 10.37, effect r = 0.73, p=3E-31; Isl2^Efna3/+ IDI_cortico vs Isl2^Efna3/Efna3 IDI_cortico, z-score = 6.93, effect r = 0.49, p=6E-13; ***p<0.001. (B, C, D, E, F) Representation and superimposition of simulated RC (retino-collicular) (white dots) and CC (cortico-collicular) (black dots) maps in WT (B), Isl2^Epha3/+ (C), Isl2^Epha3/Epha3 (D), Isl2^Efna3/+ (E) and Isl2^Efna3/Efna3 (F) animals (representative of n = 10 runs). (G) Box plot representation of median AI (from n = 20 simulated RC/CC maps) in WT, Isl2^Epha3/+, Isl2^Epha3/Epha3, Isl2^Efna3/+ and Isl2^Efna3/Efna3 animals. Mann-Whitney test: AI WT vs. AI Isl2^Epha3/+, z-score = 1.62, effect r = 0.26 p=0.10; AI WT vs. AI Isl2^Epha3/Epha3, z-score = 0.11, effect r = 0.02, p=0.90; AI WT vs AI Isl2^Efna3/+, z-score = 5.40, effect r = 0.85, p=1.45E-11; AI WT vs AI Isl2^Efna3/Efna3, z-score = 5.40, effect r = 0.85, p=1.45E-11. ***p<0.001. Abbreviations: IDI, intrinsic dispersion index; AI, alignment index; WT, wild-type; N, nasal; T, temporal; R, rostral; C, caudal; M, medial; L, lateral.

Figure 4—source data 1. Data for Figure 4A: Intrinsic Dispersion Index values for retino-collicular (RC) and cortical-collicular (CC) mapping in wild-type (WT), Isl2-Epha3KI and Isl2-Efna3KI animals.
Data for Figure 4G: Total RC and CC map alignment index (AI) values in wild-type (WT), Isl2-Epha3KI and Isl2-Efna3KI animals.

elife-59754-fig4-data1.xlsx^{(22.5KB, xlsx)}