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Impact of Xie2-64 on extracellular DA in the NAc as assessed by in vivo microdialysis. A, Systemic administration of Xie2-64 dose-dependently reduces extracellular DA in the nucleus accumbens (NAc) for over two hours post-administration. B, Intra-NAc local perfusion of Xie2-64 also decreased extracellular DA in the NAc. ***p < 0.001, **p < 0.01, *p < 0.05 compared to baseline.
