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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Neuropharmacology. 2020 May 7;176:108117. doi: 10.1016/j.neuropharm.2020.108117

Scheme 1.

Scheme 1.

Synthesis of EU-1180–438. (a) LiAlH4, THF, 0 °C to reflux, o/n, 81%; (b) methyl (2-bromomethyl)benzoate, Et3N, EtOH, rt, o/n, 62%; (c) 4-iodoanisole, CuI, Me4Phen, Cs2CO3, MePh, reflux, o/n, 73%.