Table 2.
Associations of BMI trajectories with brain volume
| Brain region | Model | F | p value | Volume by BMI trajectory groupa, Mean (SD) |
|---|---|---|---|---|
| IFG | 1 | 4.34 | 0.014* | Normal: 0.335 (0.03) |
| 2 | 4.57 | 0.012* | Overweight: 0.333 (0.04) | |
| 3 | 3.73 | 0.026* | Obese: 0.323 (0.03) | |
| MTG | 1 | 2.96 | 0.054 | Normal: 0.426 (0.04) |
| 2 | 3.39 | 0.036* | Overweight: 0.429 (0.04) | |
| 3 | 2.23 | 0.110 | Obese: 0.418 (0.04) | |
| Superior frontal gyrus | 1 | 0.03 | 0.971 | Normal: 0.300 (0.03) |
| 2 | 0.03 | 0.968 | Overweight: 0.307 (0.04) | |
| 3 | 0.30 | 0.739 | Obese: 0.308 (0.04) | |
| Middle frontal gyrus | 1 | 0.18 | 0.836 | Normal: 0.322 (0.04) |
| 2 | 0.19 | 0.831 | Overweight: 0.326 (0.03) | |
| 3 | 0.01 | 0.990 | Obese: 0.327 (0.03) | |
| Total volume (GM+WM) | 1 | 1.25 | 0.288 | Normal: 1032.176 (112.2) |
| 2 | 1.27 | 0.283 | Overweight: 1024.724 (101.2) | |
| 3 | 1.17 | 0.312 | Obese: 1037.703 (68.1) |
Model 1 adjusted for age, years of education and sex, model 2 additionally adjusted for type 2 diabetes-related characteristics (duration of type 2 diabetes, HbA1c and glucose-lowering medication for type 2 diabetes) and model 3 additionally adjusted for other cardiovascular risk factors (total cholesterol, systolic and diastolic blood pressure, and smoking status)
*
p<0.05
a
The values for each trajectory group refers to all models