Table 1.

Hematologic malignancies observed in representative studies of clonal hematopoiesis

Reference	Sequencing approach	Development of hematologic cancer with clonal hematopoiesis, HR (95% CI)	Cases of hematologic malignancy, n	Malignancy types	Hematologic malignancies in patients with preexisting clonal hematopoiesis, %
2	Whole exome	11.1 (3.9-32.6)	16	6 lymphoma NOS; 4 leukemia NOS; 2 unspecified; 2 MM; 1 MDS;1 AML	31
3	Whole exome	12.9 (5.8-28.7)	37	22 not listed; 3 CLL; 2 MDS; 2 MPN NOS; 2 AML; 1 lymphoma NOS; 2 MM or other plasma cell neoplasm; 1 CMML; 1 acute leukemia NOS; 1 chronic leukemia NOS	42
5	SNP array	35.4 (14.7-76.6)	43	Incident hematologic cancer diagnoses not specified	NA
6	SNP array	10.1 (5.8-17.7)	105	38 lymphoma; 19 MM; 14 MDS; 10 CLL; 7 AML; 4 lymphoid leukemia NOS; 3 MPN NOS 3 myeloid leukemia NOS; 2 CMML; 1 hairy cell leukemia; 1 MF; 1 CML; 1 ALL; 1 leukemia NOS	14

ALL, acute lymphoid leukemia; CLL, chronic lymphoid leukemia CML, chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; MF, myelofibrosis; MM, multiple myeloma; MPN, myeloproliferative neoplasm; NOS, not otherwise specified; SNP, single-nucleotide polymorphism.