Skip to main content
. 2020 Sep 14;10(24):11244–11263. doi: 10.7150/thno.46883

Figure 1.

Figure 1

TBC1D15 overexpression protects against cardiac injury following acute MI. A-C. Downregulation of TBC1D15 mRNA and protein level (normalized to β-Actin) in peri-infarct myocardium following 3-day MI was reversed by TBC1D15 overexpression (n = 6); D-F. Decreases of ejection fraction and fractional shortening following 3-day MI were attenuated by TBC1D15 overexpression (n = 6). Representative echocardiographic images (Scale bar = 200 ms-horizontal and 2 mm-vertical) are shown; G-H. Myocardial infarct size evoked by 3-day MI was alleviated by TBC1D15 overexpression (n = 6). Representative five consecutive sections of Evans blue/TTC staining (Scale bar = 1 mm) are displayed. AAR: area at risk; I-J. Myocardial interstitial fibrosis evoked by 3-day MI was ameliorated by TBC1D15 overexpression (n = 6). Representative five sections of Masson Trichrome staining (Scale bar = 1 mm) are illustrated; K-L. Increase of myocardial apoptosis following 3-day MI was attenuated by TBC1D15 overexpression (n = 5). Representative TUNEL/DAPI/cTnT staining images (Scale bar = 25 µm) are exhibited. The white arrows indicate the TUNEL positive nuclei. Mean ± SEM, * p < 0.05 vs. Sham-LacZ group; # p < 0.05 vs. MI-LacZ group.