Figure 4.

A-E, Non-neoplastic etiologies for subsolid nodules. A, Organizing pneumonia: 45-year-old man with cutaneous T-cell lymphoma and multiple subsolid and solid nodules, including the imaged right middle lobe nodule with coursing air bronchogram. Wedge resections of multiple nodules, including the right middle lobe nodule, demonstrated organizing pneumonia. B, Fungal infection: 26-year-old woman with multiple predominately solid nodules with ground-glass halo and recent history of cave-diving. Percutaneous core biopsy specimen revealed non-necrotizing granulomatous inflammation with Grocott methenamine silver-positive structures suggestive of fungal organisms. C, Focal fibrosis: 46-year-old woman with history of smoking and mildly fluorodeoxyglucose-avid left upper lobe part solid nodule, with linear pleural extension. Percutaneous core biopsy revealed fibroelastic scar. D, Drug reaction: 59-year-old man on immunotherapy for renal carcinoma, with the emergence of multiple bilateral ground-glass nodules coinciding with an increase in dosage of immunotherapy. E, Alveolar sarcoid: 63-year-old man with World Trade Center Ground Zero exposure and left upper lobe subsolid lesions. The dominant mass appears to be a confluence of perilymphatic micronodules, compatible with pathologically proven alveolar sarcoid post-left upper lobectomy.