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. Author manuscript; available in PMC: 2020 Nov 27.
Published in final edited form as: Nature. 2020 May 27;583(7814):122–126. doi: 10.1038/s41586-020-2337-2

Figure 4 -. Direct oxidation of free hepatic cytosolic NADH improves glucose tolerance and hepatic insulin sensitivity in vivo.

Figure 4 -

Effects of hepatic LbNOX expression on (a) plasma αHB and (b) glucose tolerance in chow fed (CFD) or high-fat diet (HFD) mice. Effect of hepatic LbNOX in HFD-fed mice during hyperinsulinemic-euglycemic clamp on (c) basal hepatic glucose production (HGP), (d) clamp hepatic glucose production. p values were determined using unpaired two-sided Student’s T test (b-d), or one-way Anova with post-hoc Tukey’s HSD test (a). Data are mean ± s.e.m from n=6–8 mice for (a), 9–10 for (b), 8–9 total for (c).