Adverse event, (≥10%)	All treatment (n = 30)		Post‐reduction (n = 26)
	All grade, n (%)	Grade 3–4, n (%)	All grade, n (%)	Grade 3–4, n (%)
Any cause	30 (100)	14 (47)	24 (92)	4 (15)
Diarrhea	29 (97)	3 (10)	7 (27)	0 (0)
Rash/acne	22 (73)	2 (4)	14 (54)	1 (4)
Paronychia	18 (60)	4 (13)	15 (58)	1 (4)
Stomatitis	18 (60)	2 (7)	5 (19)	0 (0)
Elevation of AST/ALT	11 (37)	3 (10)	6 (24)	2 (8)
Anorexia	8 (27)	2 (7)	0 (0)	0 (0)
Pruritus	6 (20)	0 (0)	2 (8)	0 (0)
Dry skin	4 (13)	1 (3)	3 (12)	0 (0)
Anemia	5 (17)	0 (0)	3 (12)	0 (0)
Interstitial lung disease	3 (10)	1 (3)	2 (8)	0 (0)
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.
Adverse Events Legend
The rate of all‐cause AEs grade ≥ 3 was 57% (17 of 30). Interstitial lung disease occurred in three patients, and one patient died. Two treatment‐related deaths from interstitial lung disease, and acute cardiac failure were observed.