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The kinetics of IgG avidity maturation during SARS-CoV-2 infection was studied. The IgG avidity assay used a novel label-free immunoassay technology. It was found that there was a strong correlation between IgG avidity and days since symptom onset, and peak readings were significantly higher in severe than mild disease cases.
Keywords: COVID-19, SARS-CoV-2, antibody avidity, label-free immunoassay, thin-film interferometry
