Table 2. Outcome parametersa at peak C-reactive protein stratified for survival and non-survival.
| Total (n = 398) |
Non-survivors (n = 54) |
Survivors (n = 344) |
Estimate with 95% CIb |
p valuec | Not knownd |
||
|---|---|---|---|---|---|---|---|
| Thromboembolic event | 14/398 (3.5%) | 2/54 (3.7%) | 12/344 (3.5%) | 0.94 (0.2 to 8.89) | 1 | 0/0 | |
| Bleeding complication | 20/398 (5%) | 9/54 (16.7%) | 11/344 (3.2%) | 0.17 (0.06 to 0.48) | 0.0004 | 0/0 | |
| Creatinine [mg/dl] | 0.45 (0.3–0.72) | 0.58 (0.37–0.93) | 0.43 (0.3–0.71) | 0.12 (−0.01 to 0.25) | 0.0645 | 21/92 | |
| Bilirubin [mg/dl] | 1.05 (0.44–4.49) | 1.78 (0.74–8.01) | 1 (0.43–4.16) | 0.56 (−0.07 to 2) | 0.0761 | 28/201 | |
| D-dimer [µg/l] | 1421 (547.5-4595) | 1506 (310–8037) | 1402.5 (574-4314.5) | −96.59 (−589.88 to 728) | 0.6278 | 17/170 | |
| Fibrinogen [mg/dl] | 462 (314–632) | 283.5 (186–476.25) | 484 (337–650) | −165 (−237 to −88) | 0.0001 | 14/119 | |
| Antithrombin [%] | 63 (46.5–80.5) | 50.5 (41.25–64.75) | 65 (48–82) | −13 (−21 to −4) | 0.0033 | 16/147 | |
| Activated partial thromboplastin time (aPTT) [s] |
46 (37–57.5) | 63.5 (50.75–76.25) | 45 (36–54) | 18 (11 to 25) | <0.0001 | 20/123 | |
| Prothrombin time (PT, Quick) [%] |
68 (50–84) | 49 (36–71.5) | 71.5 (55–85) | −19 (−27 to −11) | <0.0001 | 19/122 | |
| C-reactive protein [mg/dl] | 15.23 (6.44–26.18) | 16.83 (7.04–33.21) | 14.85 (6.44–25.15) | 2.74 (−0.86 to 7.6) | 0.1431 | 2/0 | |
| Procalcitonin [mg/dl] | 11.3 (2.41–40.31) | 9.15 (4.45–39.48) | 11.71 (1.9–39.95) | 1.26 (−6.65 to 7.63) | 0.6081 | 36/221 | |
| Hemoglobin [g/l] | 110.5 (97–130.75) | 113 (89–126.5) | 110 (97–131) | −4 (−22 to 14) | 0.7122 | 43/221 | |
| Platelets [G/l] | 145 (60–250.5) | 53 (25–103) | 163 (81–260) | −86 (−119 to −54) | <0.0001 | 1/10 | |
| Neutrophils [G/l] | 7.45 (3.62–14.05) | 9.9 (5.27–29.42) | 7.1 (3.6–13.33) | 3.5 (−0.3 to 8.4) | 0.0853 | 34/182 | |
| Interleukin 6 [ng/l] | 120.2 (34–344.35) | 584.85 (342.27–827.42) | 120.2 (33.5–276.4) | 117.22 (−358.2 to 1049.3) | 0.3309 | 52/319 | |
| Leukocytes [G/l] | 11.1 (5.9–17.85) | 8.45 (1.87–22.43) | 11.4 (6.15–17.45) | −1.1 (−4.4 to 1.8) | 0.4045 | 6/9 | |
| Base excess arterial | −1 (−4.05–1.25) | −1 (−6.22–2.7) | −1 (−3.9–0.9) | −0.2 (−3 to 1.8) | 0.7468 | 28/223 | |
Notes.
a
Data are presented as medians (25th–75th percentile).
b
Estimated median difference.
c
Differences between survivors and non-survivors assessed with the Wilcoxon rank sum test.
d
Number of missing measurements in survivors/non-survivors.