. 2020 May 22;158(4):1526–1534. doi: 10.1016/j.chest.2020.04.066

Table 2.

Biomarker Survival Association Stratified by Antifibrotic Exposure

Biomarker	AF Nonexposed (n = 172)			AF Exposed (n = 68)
Biomarker	Optimal Threshold	HR	95% CI	Optimal Threshold	HR	95% CI
CA-125	225 pg/mL	2	0.73-5.5	100 pg/mL	4.27^a	1.23-14.8
CXCL13	140 pg/mL	1.74^a	1.12-2.7	209 pg/mL	3.48^a	1.25-9.66
MMP7	3.4 ng/mL	1.65^a	1.06-2.58	5.1 ng/mL	3.87^b	1.58-9.47
SP-D	30 ng/mL	2.69^b	1.48-4.88	33 ng/mL	1.25	0.51-3.06
YKL-40	85 ng/mL	1.58	0.98-2.54	101 ng/mL	4.9^b	2.01-11.96
VCAM-1	1,600 ng/mL	2.26^b	1.32-3.87	1,520 ng/mL	2.81	0.82-9.65
OPN	47 ng/mL	1.72^a	1.04-2.84	58 ng/mL	3.37^a	1.11-10.2

HR = hazard ratio. See Table 1 legend for expansion of other abbreviations.

P ≤ .05.

P ≤ .01.