Objective
To evaluate a protocol of universal symptom and viral screening prior to initiation of controlled ovarian hyperstimulation among patients receiving care in New York City.
Design
Prospective cohort study.
Materials and Methods
Prior to initiation of controlled ovarian hyperstimulation for oocyte cryopreservation or in vitro fertilization cycles, patients were screened by phone for symptoms of fever, cough, sore throat, recent travel or contact with confirmed COVID cases. If negative, patients were scheduled for nasopharyngeal swabs at our center the following day, with visits spaced at 15 minute intervals to avoid crowding. Upon presentation for swab testing, patients were again screened for symptoms and fever. Nasopharyngeal swabs were collected in accordance with the Center for Disease Control (CDC) guidelines, and delivered to the university’s clinical microbiology laboratory. The swabs were tested using the Roche Cobas 6800 SARS-CoV-2 test, a qualitative assay, using real-time reverse transcriptase polymerase chain reaction (RT-PCR) test (Roche Diagnostics, USA), with results delivered in the same day. A negative test result was required prior to patients' baseline ultrasound and bloodwork the following morning. This study was conducted from April 21- May 21, 2020,
Results
The study sample included 151 asymptomatic patients who were tested for SARS-CoV-2 via nasopharyngeal swab. Overall, 149 (98.68%) tested negative for COVID-19, 1 (0.66%) tested indeterminate, 2 (1.32%) tested invalid, and 0 (0%) tested positive for COVID-19. Of the 149 patients who have tested negative, 81 have successfully undergone oocyte retrieval without complications. One patient screened positive for symptoms at the time of swab presentation and was instructed to return for testing in 2 weeks.
Conclusions
The incidence of COVID-19 infection among asymptomatic patients seeking fertility treatment in NYC is low. We have demonstrated that fertility care can safely resume in a way to limit risk to our patients, staff, and our physicians working in the epicenter of infection.
P-177 4:30 PM Saturday, October 17, 2020