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. 2020 Sep 13;12(9):1020. doi: 10.3390/v12091020

Table 3.

Mutational profile of CHIK/PNRCNG/LNSP_INMI1-2019 and CHIK/PNRCNG/LNSP_INMI2-2019 (in bold characters) compared to the 60 full genome sequences included in the phylogenetic analysis (see Figure 2). The upper part of the table includes sequences carrying the original amino acid (A) at position E1-226; the lower part includes sequences with the E1-A226V mutation. The 1953 Tanzanian strain (S27), used as reference, is in the first row.

Polyprotein ORF 1 ORF 2
Amino acid position 476 665 680 1705 1857 1918 1948 2144 62 404 489 530 589 637 700 711 1020 1035 1078 1093 1126 1131
Protein nsP1 nsP2 nsP3 nSP4 C E2 E1
Amino acid position 476 130 145 372 524 55 85 281 62 79 164 205 264 312 375 386 211 226 269 284 317 322
Strains non carrying the A226V mutation
AF369024 Tanzania 1953 P H E D R S R V R G A G V T S V K A M D I V
LC259094 Angola 2016 E T V A
MF503628 Hong Kong 2016 Y D N E T A M T A E V E A
EF027136 India 2006 E T M T A V E A
JF274082 India 2006 R E T M T A V E A
FJ000067 India 2006 E T M T A V E A
EF027139 India 2000 R E T V A
HM045793 CAR?? E T V A
AF490259 Tanzania 1953 R E .
HM045813 Gibbs India 1963 . E D E A
KY703926 Nicaragua 2015 E D E A
KJ689453 Yap 2013 E D E A
KY415985 Haiti 2014 E D E A
LN898109 Martinique 2014 E D E A
LN898112 Martinique 2014 E D E A
HM045786 Nigeria 1964 G E V A
AY726732 Senegal 1983 G E V A
HM045809 South Africa 1976 Q E V A
HM045795 South Africa 1976 E A
KY057363 India 2016 Y D N E T A M T A E . V E V A
HM045811 Tanzania 1953 E A
HM045821 Senegal 1963 R .
HM045810 Thailand 1958 E D E . A
HM045815 Senegal 1979 G E . V A
HM045820 Cote dIvoire 1993 G E . V A
AB860301 Philippines 2013 E D E A
KX496989 Colombia 2016 E D E A
EF027141 India 1973 E D E A
HE806461 New Caledonia 2011 E D E A
KF318729 China 2012 E D E A
HQ456255 Kenya 2004 E T M T A V E A
MG049915 CHIKV/ITA/Lazio-INMI1-2017 Y D E N C E T S A M T A E V E V A
MH507158 CHIKV/ITA/Lazio-INMI2-2017 Y D E N C E T S A M T A E V E V A
MF774617 Pakistan-07/2016 Q Y D N I E T A M T A E V E V A
MF774614 Pakistan-04/2016 Y D N I E T A M T A E V E V A
MF773566 Bangladesh 2017 Y D E N . E T S A M T A E V E V A
MF499120 Hong Kong 2016 Y E T A M T A E V E V A
HM045805 South Africa 1976 E X A
HM045792 South Africa 1956 E A
MH423806 Kenya 2016 E T A M T A E V E A
HQ456253 East Africa 2004 E T M T A V E A
HM045809 DRC 1960 Q E V A
HM045822 CAR 1978 E T V A
KY038946 CAR 1975 E T V A
KY038947 CAR 1983 Q E T V A
HM045812. Uganda 1982 E T V A
MK120194 CHIKV/Italy/Calabria-ISS-1/2017 Y D E N C E T S A M T A E V E V A
MK120196 CHIKV/Italy/Calabria-ISS-989/2017 Y D E N C E T S A M T A E V E V A
MH754507 CHIKV/Italy/Lazio-ISS-1/2017 Y D E N C E T S A M T A E V E V A
Strains carryng the A226V mutation
CHIK/PNRCNG/LNSP_INMI2-2019 E T D V V A
CHIK/PNRCNG/LNSP_INMI1-2019 E T D V V A
KT449801 Reunion 2006 E T M T A V V E A
EU244823 Italy 2007 E T M T A V V E A
KX262993 Italy 2007 E T M T A V V E A
KX262989 Italy 2007 R E T M T A V V E A
KP003813 Congo 2011 E T V V A
KP003812 Gabon 2007 E T V V A
FJ807899 Malasya 2008 E T M T A V V E A
EU372006 India 2007 E T M T A V V E A
FJ959103 Mauritius 2006 E T M T A V V E A
EF012359 Mauritius 2006 E T M T A V V E A
KP003808 Madagascar 2006 Q R E T M T A V V E A