Table 1.
CC50, EC50 and SI of the compounds on ZIKV Paraiba/2015 replication (post-infection).
| Compound | CC50 (MTT) (µM) | CC50 (XTT) (µM) |
EC50 (µM) |
SI (MTT) | SI (XTT) |
|---|---|---|---|---|---|
| Antimycin A | 51.28 | >1350.00 | 2.00 | 25.64 | >675.00 |
| OSU-03012 | 6.39 | 132.50 | 8.40 | 0.76 | 15.77 |
| Obatoclax | 17.57 | 60.44 | 0.63 | 27.89 | 95.94 |
| Azauridine | 155.80 | >1350.00 | 4.29 | 36.32 | >314.69 |
| Azaribine | 237.00 | >1350.00 | 1.62 | 146.29 | >833.33 |
| Pyrazofurin | 270.60 | >1350.00 | 5.96 | 45.35 | >226.51 |
| Mycophenolate mofetil | 166.30 | >1350.00 | 3.52 | 47.24 | >383.52 |
| Mycophenolic acid | 275.40 | >1350.00 | 4.26 | 64.65 | >316.90 |
| AVN-944 | 272.60 | >1350.00 | 0.98 | 278.16 | >1377.55 |
| Brequinar | 237.70 | >1350.00 | 1.51 | 157.42 | >894.04 |
| ATA | >1350.00 | >1350.00 | 25.00 | >54.00 | >54.00 |
CC50: median 50% cytotoxicity concentration; EC50: median 50% effective concentration; SI: selective index (CC50/EC50).