Table 4.
Mean NI antibody titers against H3N2 influenza strains used for immunization and antigenically distinct N2 strains in pigs of different vaccine groups.
| Geomean NI Titers Per Group at: | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Week 9 | Week 13 | ||||||||||
| Virus Strains | Inf.: 1°: 2°: |
NC95 PBS PBS |
NC95 G08 G08 |
NC95 PA10 PA10 |
NC95 G08 PA10 |
NC95 PA10 G08 |
NC95 PBS PBS |
NC95 G08 G08 |
NC95 PA10 PA10 |
NC95 G08 PA10 |
NC95 PA10 G08 |
| EU swine | |||||||||||
| G08 | 7 | 557 | 320 | 844 | 485 | 15 | 5881 | 1689 | 1940 | 2941 | |
| G12 * | 5 | 557 | 121 | 106 | 184 | 10 | 139 | 735 | 184 | 368 | |
| N.A swine | |||||||||||
| TX98 | 23 | 485 | 844 | 422 | 1470 | 23 | 279 | 1470 | 368 | 1114 | |
| PA10 | 7 | 640 | 2560 | 485 | 4457 | 11 | 485 | 17,829 | 1470 | 10,240 | |
| IN11 | 8 | 640 | 1689 | 640 | 2229 | 35 | 1689 | 35,658 | 3880 | 23,525 | |
| IA11 | 26 | 114 | 2229 | 1280 | 4457 | 23 | 557 | 5881 | 970 | 4457 | |
| MO15 | 8 | 243 | 485 | 243 | 735 | 9 | 211 | 1114 | 320 | 320 | |
| Human | |||||||||||
| NC95 | 139 | 2941 | 3378 | 2941 | 6756 | 106 | 1689 | 5120 | 2560 | 6756 | |
| PER09 | 5 | 11 | 10 | 6 | 30 | 5 | 13 | 80 | 15 | 40 | |
| VIC11 | 8 | 40 | 46 | 23 | 80 | 7 | 20 | 70 | 35 | 121 | |
Inf., 1°, 2°: virus strains used for infection, first, and second vaccination. NI: Neuraminidase Inhibition. NI antibody titers were determined 2 weeks after the first (week 9) and second (week 13) vaccinations. The starting dilution in the ELLA assays was 1:10. NI antibody titers below 10 were assigned a titer of 5. Five pigs were examined per group. The virus belonging to the H1N2 subtype is shown with an asterisk (*). Full virus names: G08; A/Swine/Gent/172/2008, G12; A/swine/Gent/26/2012, TX98; A/swine/Texas/4199-2/1998, PA10; A/swine/Pennsylvania/A01076777/2010, IN11; A/Indiana/08/2011, IA11; A/swine/Iowa/A01049750/2011, MO15; A/swine/Missouri/A01840724/2015, NC95; A/Nanchang/933/1995, PER09; A/Perth/16/2009, VIC11; A/Victoria/361/2011.