Figure 1.

Schematic diagram of glial change in oxaliplatin-induced neuropathic pain. Administration of oxaliplatin induced astrocytes and microglia activation increase in the brain and spinal cord of rodents. The morphology of astrocytes and microglia changes to hypertrophic soma with thick processes and hypertrophic amoeboid shape soma with short processes, respectively. In the peripheral nervous system, SGCs in the DRG significantly increase their activity and coupling rate with SGCs surrounding neighboring neurons. These glial changes in the brain, spinal cord, and DRG may play an important role in the development and maintenance of oxaliplatin-induced neuropathic pain.