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. 2020 Sep 18;8(9):361. doi: 10.3390/biomedicines8090361

Figure 13.

Figure 13

Effect of pyrithiamine (PT) on the intracellular content of thiamine and ThDP and cell survival in the presence of PQ in Neuro2a cells (A–C) and the intracellular content of thiamine and ThDP or NO production in the presence of LPS in BV2 cells (D–F). The cells were incubated in the presence of DBT 25 µM with or without PT 25 μM for 25 h. PQ (0.25 mM) or LPS (1 µg/mL) were added 1 h after addition of PT or DBT. The results are expressed as mean ± SD (n = 3). Statistical analysis was made by one-way ANOVA followed by Tukey multiple comparisons test (**, p < 0.01; ***, p < 0.001).