Table 4.
In vitro antileishmanial activity expressed as concentrations inhibiting the parasite growth by 50 and 90% (IC50 and IC90, respectively) on L. infantum promastigotes and amastigotes and selectivity index (SI) in bone marrow-derived macrophages (BMDM) after 48 h of treatment with free BER, LP-BER and amphotericin B (AmB, as positive control).
| Drug | Promastigotes (μM) |
Amastigotes (μM) |
SI (CC50/IC50) |
|---|---|---|---|
| BER IC50 | 5.2 ± 0.1 | 1.1 ± 0.1 | 115.0 |
| BER IC90 | 46.6 ± 0.1 | 9.8 ± 0.1 | – |
| LP-BER IC50 | 6.8 ± 0.6 | 1.4 ± 0.2 | >714.3 |
| LP-BER IC90 | 60.8 ± 0.6 | 12.2 ± 0.2 | – |
| AmB IC50 | 1.4 ± 0.3 | 1.3 ± 0.2 | 3.5 |
| AmB IC90 | 12.6 ± 0.3 | 11.4 ± 0.2 | – |