Figure 5.

Differences in the functional analysis of the gut microbiome in mouse models of TRPA1 knockout, TRPV1 knockout and TRPA1V1 double-knockout. (a) The abundance of the predicted gut microbial metagenomic functions related to the lipids and fatty acids biosynthesis and metabolism pathways (Level 3 Kyoto encyclopedia of genes and genomes (KEGG) pathway) in mouse models of TRPA1 KO, TRPV1 KO and TRPA1/V1 dKO as well as in TRP-WT counterparts. (b) The hierarchical heat-map depicting the correlation of specific gut bacterial phyla, families and genera with functional metagenomic KEGG pathways related to the biosynthesis and metabolism of lipids and fatty acids.