Table 1.
Experimental runs, independent variables and measured responses in 23 factorial design for SV-loaded nano-spanlastics.
| Formula Code | Variables | ||||
|---|---|---|---|---|---|
| Independent | Dependent | ||||
| X1 | X2 | X3 | Y1 * | Y2 * | |
| F1 | −1 | −1 | −1 | 79.44 ± 1.15 | 63.84 ± 1.75 |
| F2 | −1 | −1 | 1 | 70.18 ± 0.62 | 68.59 ± 1.82 |
| F3 | −1 | 1 | −1 | 82.30 ± 0.98 | 72.59 ± 1.12 |
| F4 | −1 | 1 | 1 | 79.48 ± 1.33 | 83.09 ± 1.79 |
| F5 | 1 | −1 | −1 | 95.53 ± 1.46 | 70.29 ± 2.14 |
| F6 | 1 | −1 | 1 | 90.32 ± 2.18 | 78.59 ± 1.53 |
| F7 | 1 | 1 | −1 | 97.68 ± 1.93 | 76.58 ± 1.29 |
| F8 # | 1 | 1 | 1 | 93.34 ± 0.92 | 90.27 ± 1.98 |
| Independent Variables | Low (−1) | High (+1) | |||
| X1: Ratio of Span 60 to EA | 60:40 | 80:20 | |||
| X2: Type of EA | Tween 80 | Cremophor RH | |||
| X3: Rotation speed (rpm) | 500 | 1000 | |||
Notes: Y1: EE(%), Y2: Q12h (%),* the values are expressed as mean ± SD; n = 3, # Optimized Formulation, all formulations contained 8.3% SV. Abbreviations: EE, entrapment efficiency; Q12h, drug released after 12 h; EA, edge activator.