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Synergistic effect of pitavastatin and isavuconazole. The phase contrast microscope images show A. castellanii Ma trophozoites treated for 48 h with 0.5% DMSO and a combination of 2.2 μM of pitavastatin and 0.001 µM of isavuconazole. The drug-treated A. castellanii cells are rounded, and much smaller in size, whereas DMSO-treated cells are irregularly shaped with visible cytoplasm. Magnification, ×20.
