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Pimozide inhibits STAT3 signaling. Approximately, 0.7 million of (A) U-87 MG, (B) U-251 MG, (C) GBM28, and (D) Daoy cells were treated with 5, 10, 15, and 20 µM pimozide for 48 h. Representative blots showing a concentration-dependent effect of pimozide on pSTAT3 (Tyr705), STAT3, p-SRC (Tyr416), c-Myc, Mcl-1, Bcl-2, cleaved caspase 3, and cleaved PARP. β-actin was used as a loading control. Figures shown are the representative blots of at least three independent experiments.
