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. 2020 Aug 24;8(9):1287. doi: 10.3390/microorganisms8091287

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Structural analysis of CVB3 virus-like particle. (A) Field view of cryo-EM micrographs of frozen-hydrated CVB3-VLPs. (B) A gallery of selected particles used towards structure determination (inverted). (C) Particle sorting by scale factor using Polar Fourier Transform method. Particles within ±3% of the average were used to calculate 2D-referece-free class averages shown in (D). (E) 3D surface rendering 2-fold view of CVB3-VLP colored by radial distance from cold to warm. A depression at 2-fold axis is pointed out. (F,G) Rigid-body fitting and dynamic flexible fitting of CVA6-VLP into cryo-EM density revealing the expanded size as a result of 2-fold depression.