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. 2020 Sep 17;9(9):2113. doi: 10.3390/cells9092113

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The combined versatility in HA chemical modifications and processing enables fabrication of a wide range of HA-based materials. (A) Hydrogels are the most common HA-based material employed in CNS applications and are beneficial due to their ease of formation. (B) Granular hydrogels (or microgels) offer improved mass transport through the interstitial space between particles. (C) Composite systems incorporate multiple phases and/or materials to add multifunctionality to the scaffold. HA-based materials can be designed for minimally invasive injection into CNS tissue to promote healing and regeneration, including (D) spinal cord injury and (E) traumatic brain injury.