Table.

Hazard Ratios for Incident Cardiovascular Disease Diagnoses in Expanded Multivariable Models^a

	Surgical premature menopause			Natural premature menopause
Diagnosis	Hazard ratio (95% Cl)		P valueb	Hazard ratio (95% Cl)		P valueb
First cardiovascular disease diagnosisc	1.74(1.25–2.42)		<.001	1.30(1.13–1.51)		<.001
Coronary artery disease	2.34(1.35–4.06)		.002	1.34(1.01–1.78)		.04
Heart failure	2.65(1.22–5.79)		.01	1.24(0.81–1.89)		.32
Aortic stenosis	4.20(1.26–13.95)		.02	2.72(1.61–4.60)		<.001
Mitral regurgitation	4.10(1.60–10.53)		.003	0.72(0.33–1.56)		.40
Atrial fibrillation	1.52(0.85–2.72)		.15	1.22(0.96–1.55)		.11
Ischemic stroke	0.50(0.07–3.61)		.49	1.62(1.07–2.47)		.02
Peripheral artery disease	1.26(0.30–5.26)		.75	1.30(0.75–2.25)		.35
Venous thromboembolism	2.28(1.19–4.36)		.01	1.56(1.14–2.13)		.005

^aModels are adjusted for age, race/ethnicity, prevalent type 2 diabetes, ever having smoked, systolic blood pressure, use of antihypertensive medication, non-high-density lipoprotein cholesterol, use of cholesterol-lowering medication, body mass index, C-reactive protein, history of menopausal hormone therapy use, chronic kidney disease, frequency of alcohol intake, history of cancer, and history of hysterectomy.

^bDerived from Cox proportional hazards models.

^cComposed of coronary artery disease, heart failure, aortic stenosis, mitral regurgitation, atrial fibrillation, ischemic stroke, peripheral artery disease, and venous thromboembolism.