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. 2020 Aug 25;69(11):2446–2457. doi: 10.2337/db20-0579

Figure 4.

Figure 4

Verteporfin (Vert) or RPTC-specific YAP deletion reduced ECM and α-SMA expression in diabetic kidneys. A: Verteporfin inhibited upregulation of collagen I and α-SMA in unilateral nephrectomized diabetic FVB/NJ mouse renal cortical tissue lysates. B: Representative IF of verteporfin inhibition of collagen I and α-SMA (original magnification ×200). C: Fibronectin and α-SMA upregulation in diabetic kidneys were significantly inhibited in YapPTiKO mice. D: Representative IF indicated inhibition of α-SMA expression and Ki67-positive cells in the YapPTiKO mouse kidneys (original magnification ×200). Values are mean ± SEM (n = 4–10 for each group). **P < 0.01, ***P < 0.001. HPF, high power field.