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Clearance of mAbs in naïve Tg32, naïve Tg32-hFc, immunized Tg32, IVIg-preloaded Tg32, and naïve Fcgrt KO mice. (a) Plasma concentration-time course and (b) β-phase half-lives of HuLys11. (c) Log-linear plasma concentration-time course and (d) β-phase half-lives of trastuzumab. Mean ± SEM of cohorts from (a). ND, Half-life of Fcgrt KO mice too low to be computed.
