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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Prev Sci. 2020 Nov;21(8):1048–1058. doi: 10.1007/s11121-020-01157-9

Reconnecting Homeless Adolescents and Their Families: Correlates of Participation in a Family Intervention

Norweeta G Milburn 1, Alexandra M Klomhaus 2, W Scott Comulada 3, Susana A Lopez 4, Eraka Bath 5, Bita Amani 6, Jessica Jackson 7, Alex Lee 8, Eric Rice 9, Alan Semaan 10, Bo-Kyung Elizabeth Kim 11
PMCID: PMC7577401  NIHMSID: NIHMS1624723  PMID: 32857298

Abstract

Behavioral family interventions are an effective way to intervene to prevent negative developmental outcomes for adolescents. Participation in family interventions encompasses behavioral and cognitive/attitudinal dimensions, among others, indicated by retention and engagement, respectively. Two dimensions of participation, retention and engagement, in a family intervention were examined in a sample of newly homeless adolescents and their parents or guardians. Correlates of participation included parents with more income and less perceived family conflict, and adolescents with higher endorsement of depressive, anxiety, somatizing, obsessive-compulsive, phobic, and psychotic symptoms on the Brief Symptom Inventory (BSI). Stronger therapeutic alliance was correlated with being more distressed (i.e. lower income, more hostility), being a female adolescent participant, and having greater comfort discussing sex with parents. Furthermore, parents and adolescents with greater distress and thus greater need were more apt to finish the intervention. The finding that families who were experiencing more distress had higher alliance scores suggests that there is an additional need for development of interventions for families in crisis. Both participant and provider perceptions are also important in development of a strong therapeutic alliance. This study’s findings have implications for further exploration of the development of cultural humility and improving mental health literacy among facilitators of behavioral interventions.

Keywords: homeless adolescents, youth high-risk behaviors, family conflict, family interventions, intervention engagement


There is a large unmet need for family interventions for homeless adolescents. Family interventions with homeless adolescents are, however, a relatively unexplored area (Pergamit, Gelatt, Straford, Beckwith, and Martin 2016) even though their family relationships are often characterized by conflict, inappropriate problem-solving and poor communication (Tyler and Schmitz 2013). While research demonstrates that newly homeless adolescents will return home (Milburn et al. 2007), those who have more troubled relationships with their parents have a more difficult time remaining at home (Milburn et al. 2009). Getting homeless adolescents and their families to participate in family interventions, crucial for intervention effectiveness, is a known challenge (Spoth and Redmond 2000), especially for at-risk adolescents (e.g., Rotheram-Borus, Goldstein and Elkavich 2002) that often have low completion rates (Milburn and Lightfoot 2016). This may be due to barriers to participating in terms of access, relevance, and time commitment (Coatsworth, Hemady, and George 2018). One strategy often used for increasing access for these challenged families is to provide family interventions during key life transitions for adolescents when families naturally partake in their children’s activities (e.g., graduation) and, thus, might be receptive to participating in an intervention that could help with the transition (Coatsworth, Duncan, Pantin, and Szapocznik 2006). For homeless adolescents, a key life transition time may be when they first leave home, are newly homeless, and may want to reconnect via a family intervention. The success of this strategy, however, has been limited for homeless adolescents (Coatsworth et al. 2006).

The importance and challenges of participation in interventions have been highlighted as key area for further research in Type 2 translation research to implement and scale up evidence-based interventions by Spoth et al. (2013). Identifying the “key factors” and “best strategies for enhancing participation” are critical to the Implementation Phase of their Translation Science to Population Impact (TSci Impact) Framework (Spoth et al. 2013, p. 325). Mauricio, Gonzales and Sandler (2018) have applied the TSci Impact Framework specifically to family interventions to highlight areas for further research. These included the need to have consistent definitions of participation and to define participation in terms of both behavioral and attitudinal/cognitive dimensions. This work provides an overarching frame for our examination of participation in a family intervention for homeless adolescents. Retention, as indicated by attendance over time, is one aspect of the behavioral dimension (e.g., Murry, Berkel, and Liu 2018) while treatment satisfaction is one attitudinal/cognitive dimension of engagement (Coatsworth et al. 2018; Mauricio et al. 2018).

Like other studies of intervention implementation, retention, the behavioral dimension, was operationalized as the completion of a substantial portion of the intervention (Ingoldsby 2010). Engagement, the attitudinal/cognitive dimension, was operationalized as satisfaction with the therapeutic alliance between the families and the intervention facilitators—it is treatment satisfaction (Mauricio et al. 2018). A personal bond with a treatment provider positively impacts family engagement in therapeutic interventions (e.g., Elvins and Green 2008; Thompson, Bender, Lantry, and Flynn 2007). Staudt (2007) proposed a framework for thinking about family engagement that is closely aligned with the conceptual framework of Mauricio et al. (2018) (i.e., in-session engagement) in that it takes into account the attitudinal component of engagement, in addition to the behavior of the facilitator. The attitudinal component of engagement is related to five dimensions: intervention relevance and acceptability, daily stresses, external barriers to the intervention, cognitions about the intervention, and the therapeutic alliance. We focus on one of these dimensions, the therapeutic alliance, because this dimension is an indicator of a personal bond between the facilitator and family (Coatsworth et al. 2018).

Many studies assert that better retention is associated with demographics such as higher levels of income and educational attainment, family characteristics such as having more family stress, and intervention characteristics such as trust (Coatsworth et al. 2006; Winslow, Bonds, Wolchik, Sandler, and Braver 2009); however, findings are mixed and evidence is still emerging relevant to culturally humble ways of engaging participants (e.g., Murry et al. 2018). Engagement has been associated with demographics such as higher levels of educational attainment and family characteristics such as parental involvement (Coatsworth et al. 2018). Interventions having project goals that are consistent with the goals of the parent/adolescent are also linked to better retention (Winslow et al. 2009). While previous research has emphasized the importance of addressing how to best engage and retain participants in interventions to reach more families and have more widespread intervention uptake, more research defining and examining contextual factors related to participation is needed (Milburn and Lightfoot 2016; Mauricio et al. 2018). Specifically, given high levels of current mental and behavioral problems among homeless adolescents – identified as potential barriers to participation – further understanding how these issues as well as their readiness to change might relate to program participation would be informative.

Furthermore, research on how to increase participation in family interventions has often only examined one dimension of participation (see Milburn and Lightfoot 2016 for a review), and many studies have focused on the behavioral dimension (Mauricio et al. 2018). In this manuscript, we examine the association of demographic, family, and intervention characteristics with two dimensions of participation, retention and treatment satisfaction, in a sample of participants in STRIVE (Support To Reunite, Involve, and Value Each other), a family intervention for homeless adolescents and their parents or guardians that has been found to be efficacious in reducing delinquent behaviors, substance use, and sexual risk taking behaviors (Milburn et al. 2012). We explore how individual characteristics of parents and adolescents (e.g., demographic characteristics, mental health, substance use, readiness to change behaviors as well as sexual practices/behaviors of adolescents) and family characteristics (e.g., family functioning, attachment/bonding, and parenting practices) relate to the retention and treatment satisfaction of homeless adolescents and their parents or guardians in STRIVE. Directional hypotheses were not made for how these individual and family characteristics would be associated with retention and treatment satisfaction. Our goal is to begin to identify how these factors relate to participation in this underserved population to gain a better understanding of how to better implement family interventions with populations that are not often provided evidence-based family interventions (Spoth et al. 2013).

Method

Procedure

From March 2006 to June 2009, newly homeless adolescents and their parents or guardians (e.g., foster parents, grandparents), who will be referred to as parents going forward, were recruited from homeless adolescent-serving, community-based organizations and from direct recruitment in Los Angeles and San Bernardino Counties to participate in a randomized controlled trial of STRIVE. STRIVE is a brief five session psychoeducational intervention administered to the adolescents and parent(s) together to improve families’ problem-solving, emotional regulation and conflict resolution skills. Eligibility criteria were that adolescents were 12 to 17 years old, away from home (e.g., in a shelter, hotel, on the street, or staying with someone other than their parent(s)) for at least two nights in the past six months, were not away from home for more than six months, and were at a transition point to reconnect with family (i.e.,had a parent who was willing to reunify with the adolescent). In addition, no current abuse or neglect, no active psychosis, or no current substance intoxication (e.g., not impaired by alcohol and/or other drug use) could be present. These additional criteria were screened for after informed consent was given during a baseline assessment. Written informed consent/assent to participate was obtained from both parents and adolescents in the study. The Institutional Review Board of the University of California at Los Angeles (UCLA) approved the protocol for this study.

After the adolescent and parent assented/consented, they completed baseline, 3, 6 and 12 months follow-up assessments. The face-to-face computerized assessments were conducted by a highly trained and ethnically/racially diverse assessment team. Audio computer-assisted self-interviewing (ACASI) was used for sensitive measures (i.e., drug and alcohol use). Eligible families (n = 151) were randomly assigned to either an intervention (n = 68) or control group (n = 83). Further details on the study design and intervention may be found in Milburn et al. (2012). This manuscript focuses on the baseline responses as they relate to attendance at intervention sessions that were scheduled to take place between the baseline and the 3 months follow-up assessment. Therefore, analyses are conducted on baseline data from the 68 adolescents and parents who were randomized to the intervention condition.

Sample

Parents.

Of the 68 parents in the intervention arm of the study, 88% were female (n = 60), and the average age was 41 years (range = 23 to 65). 57% reported their race/ethnicity as Hispanic (n = 39), 21% as Black/African American (n = 14), and 21% as White/European American (n = 14). Among the Hispanic parents, 41% were Mexican American (n = 28). 63% reported being born in the United States (US), and 60% reported their primary language to be English, followed by Spanish (38%). Parents who reported not being born in the US reported living in the US for 21 years on average (range = 6 to 38 years). Parents received a mean of 13 years of education (range = 4 to 17 years). 51% of parents reported previous year total income of less than $25,000, and 63% were currently employed. The majority of parents were either the mother (79%), father (10%), or grandparent (6%) of the adolescent in the study. 78% of parents reported their child to currently be living at home, and 4% reported in a shelter.

Adolescents.

Of the 68 adolescents in the intervention arm, 78% were female (n = 53), and the average age was 15 years (range = 12 to 17). 62% of adolescents reported their race/ ethnicity as Hispanic, 16% as Black/African American, and 10% as White/European American. 91% of adolescents were born in the US, and 87% were primarily English-speaking. 68% of adolescents had consumed alcohol in their lifetime, 56% had used marijuana, and 26.5% had used any illicit substances other than marijuana (hard drugs). Rates were lower for use in the past three months: alcohol (43%), marijuana (44%), and hard drugs (16%). Analyses of substance use focus on alcohol, marijuana, and hard drugs, due to low reported numbers of use of individual substances other than marijuana. Table 1 summarizes both parent and adolescent demographics.

Table 1.

Parent and Adolescent Demographics

Parents (N = 68)
Adolescents (N = 68)
Mean SD Mean SD
Demographics
Age 41.1 7.6 14.73 1.33
Male gender, % (n) 11.8% 8 22.1% 15
Married, % (n) 39.7% 27 n/a n/a
Race/Ethnicity, % (n)
  Hispanic 57.4% 39 61.8% 42
  Black/African American 20.6% 14 16.2% 11
  White/European American 20.6% 14 10.3% 7
  Other, Mixed Race 1.5% 1 11.8% 8
Primary language, % (n)
  English 60.3% 41 86.8% 59
  Spanish 38.2% 26 11.8% 8
  Other 1.5% 1 1.5% 1
Born in the U.S., % (n) 63.2% 43 91.2% 62
Years in the U.S. 20.8 8.5 n/a n/a
Highest year of education 13.0 3.3 n/a n/a
Currently employed, % (n) 63.2% 43 n/a n/a
Yearly income, Likert scale 5.4 3.0 n/a n/a
Child living w/biol family, % (n) 77.9% 53 n/a n/a
Relationship to adolescent in study
  Mother 79.4% 54 n/a n/a
  Father 10.3% 7 n/a n/a
  Grandparent 5.9% 4 n/a n/a
  Other 4.4% 3 n/a n/a
Sexual orientation
  Bisexual n/a n/a 11.8% 8
  Heterosexual n/a n/a 88.2% 60
Substance Use, Lifetime
  Alcohol n/a n/a 67.7% 46
  Marijuana n/a n/a 55.9% 38
  Other Drugs n/a n/a 26.5% 18
Substance Use, Last 3-Months
  Alcohol n/a n/a 43.3% 29
  Marijuana n/a n/a 44.1% 30
  Other Drugs n/a n/a 16.2% 11

Measures

Measures reported by both parents and adolescents, by parents only, and by adolescents only are summarized below. Further details on measures are found in supplementary Table S1 (available online), including the number of items, Cronbach’s alphas, reporter, and scale ranges.

Parent and adolescent report.

Demographics.

Demographic characteristics included age, gender, race/ethnicity, and primary language. Parent demographic characteristics also included Mexican versus non-Mexican Latino ethnicity, marital status, household income in the previous year, amount of money received in the previous month from all sources, highest grade/year of education completed, being born in the US, number of years living in the US, being currently employed, parent’s relationship to the child (e.g., if they were the biological parent), and whether the adolescent in the study was living with a biological parent. Household income was categorized into $5,000 increments and treated as a Likert scale, e.g., “Less than $5,000” (1), “$5,000–9,999” (2), “$35,000–39,999” (8), and “$40,000 - And Over” (9). Adolescent demographic characteristics also included sexual orientation.

Mental health.

The Brief Symptom Inventory (BSI; Derogatis 1993) assessed parent and adolescent mental health symptoms during the previous week. A global summary measure of distress was calculated along with nine sub-scales for symptoms of depression, anxiety, somatization, interpersonal sensitivity, obsessive-compulsive, hostility, phobic anxiety, paranoid ideation, and psychoticism. In addition, a binary caseness variable was calculated that provided a clinical cutoff level based on the global summary measure and the nine sub-scales as outlined in the BSI scoring manual.

Family functioning.

The Family Functioning Scale (Bloom 1985) measured parents’ and adolescents’ perception of their family’s functioning across seven different constructs: cohesion, expressiveness, disengagement, democratic family style, laissez-faire family style, authoritarian family style, and conflict. We adapted the original response scale labels “Strongly agree” to “Strongly disagree” to read as “Very true for my family” to “Very untrue for my family”.

Readiness for change.

The University of Rhode Island Change Assessment (URICA; McConnaughy, Prochaska, and Velicer 1983) assessed parents’ and adolescents’ readiness for change through four subscales: pre-contemplation, contemplation, action, and maintenance. Readiness was computed by summing the last three subscales scores and subtracting the pre-contemplation subscale score. Both the full readiness scale and subscales were examined to assess whether specific stage of readiness might be related to participation.

Substance use.

The Short Michigan Alcohol Screening Test (SMAST; Selzer, Vinokur, and van Rooijen 1975) ascertained alcohol use and abuse among parents. Problematic alcohol use was identified in one of the following three ways. Participants indicating lifetime alcohol abstinence were not administered the SMAST and classified as not engaging in problematic alcohol use. Participants who gave a “no” response to the first SMAST item, “Do you feel that you are a normal drinker?”, were classified as engaging in problematic alcohol use. Participants who indicated being a normal drinker were further queried on 12 yes-no (1–0) indicator items assessing feeling and actions related to drinking. Participants with a total score of 3 or more were also classified as problematic alcohol users as suggested by Selzer et al. (1975).

The adolescent version of the Michigan Alcohol Screening Test (MAST; Selzer 1971) was administered to adolescents. The last two items were modified and queried individuals on whether they had ever been “arrested or gotten a ticket when you have been drinking (for anything other than a DUI)” and arrested for “drunk driving”. Follow-up questions on the number of arrests were not administered. A yes-no indicator variable was created to identify borderline problematic alcohol use. Participants who indicated lifetime alcohol abstinence were not administered the MAST and were classified as not engaging in problematic alcohol use. Individual MAST items were weighted and summed based on scoring guidelines. Participants with a total score of five or more were identified as problematic alcohol users based on guidelines suggested by Selzer (1975).

The Drug Abuse Screening Test (DAST; Skinner 1982) ascertained drug use and abuse among parents through items assessing feelings and actions related to substance use. Following diagnostic validity statistics and recommendations presented in Gavin, Ross, and Skinner (1989), the presence of a substance use disorder was identified by a score of six or more. The adolescent DAST (DAST-A; Martino, Grilo, and Fehon 2000) ascertained drug use and abuse among adolescents in a similar manner.

The AIDS Risk Behavior Assessment (ARBA; Donenberg, Emerson, Bryant, Wilson, and Weber-Shifrin 2001) assessed alcohol and drug use among adolescents over their lifetime and the past three months, frequency of use in the past three months, and method of use. As a supplement to the DAST, the ARBA explicitly asks about the following substances: alcohol, marijuana, cocaine or crack, amphetamines, ice (smokable speed), heroin, a mixture of heroin and cocaine, a mixture of heroin and speed, non-prescription methadone, and other opiates. As in Milburn et al. (2012), we created yes-no composite indexes of “hard drug use” for lifetime and past-three-months use of any substance other than marijuana.

Comfort discussing sexual and reproductive health.

Teaming African American Parents with Survival Skills (TAAPSS; Bray and Pequegnat 2012) measured the degree to which a parent was comfortable discussing risk behaviors for sexually transmitted infections, including HIV/AIDS, with their child. Three summary sub-scales covered: (1) ever talking with one’s child about sex; (2) talking with one’s child about sex currently or in the past three months; and (3) talking with one’s child in general about topics that include sexuality, reproduction, alcohol and drug use in the past three months. The TAAPSS also included 11 yes-no questions for adolescents on whether their guardian discussed sexual behavior, alcohol, and drug use with them in the past three months. Items were summed.

Retention and engagement.

Retention, defined as completion of the intervention sessions by parents and their adolescent children, was ascertained by session attendance. Most parents and their adolescents (76%; n = 52 of 68 parent-adolescent pairs) attended all of the five possible sessions. Remaining parents and their adolescents attended zero to one session (n = 2), two sessions (n = 10), three (n = 3), or four sessions (n = 1). Hence, we created a binary outcome for attendance, classified as having attended all five sessions versus fewer than five sessions. Engagement, defined as satisfaction with the therapeutic alliance, was assessed by the Working Alliance Inventory, Short Form (WAI; Busseri and Tyler 2003). A higher WAI summary score indicates a better working relationship and trust between facilitator and participant. Scores were reported for facilitators (n = 38) and participants (n = 40, for parents and adolescents, respectively). Correlation between facilitator and participant scores was low for parents (r = .31) and moderately high for adolescents (r = .75). On average, parent-reported scores were 3 points higher than facilitator reported scores (paired t = 2.35, df = 36, p = .03); adolescent and facilitator-reported scores did not differ significantly.

Parent report.

The Conflict Tactics Scales, Form A (Strauss 1979) ascertained the frequency of parent conflict with the adolescent over the past three months or currently across three scales: reasoning, verbal aggression, and physical violence. The Parker Parental Bonding Instrument (Parker, Tupling, and Brown 1979) assessed parent perception of the degree of bonding between adolescent and parent across two subscales, care and protection. The Adult Attachment Scale (Collins and Read 1990) ascertained adult attachment styles and closeness of relations with partners and other individuals across three subscales: difficulty in depending on others, and anxiety and discomfort in closeness to others. Higher scores represent less secure attachment.

Adolescent report.

Emotional regulation.

The Difficulties in Emotion Regulation Scale (Gratz and Roemer 2004) measured components of emotional regulation among adolescents and was analyzed as a summary measure of the first 14 items from the original 36-item scale.

Trauma.

The adolescent version of the UCLA Post Traumatic Stress Disorder (PTSD) Reaction Index (UCLA PTSD-RI) for DSM-IV (Steinberg, Brymer, Decker, and Pynoos 2004) assessed adolescents’ exposure to traumatic events (Criterion A), symptoms of PTSD (Criteria B, C, D), and DSM-IV PTSD diagnostic criteria. Criteria B, C, and D represent re-experiencing, avoidance, and increased arousal symptoms, respectively. Items are scored from 0 (None) to 4 (Most). Based on the UCLA PTSD-RI manual, responses of 2 (Some) or higher indicate the presence of symptoms for individual items. Partial PTSD is considered likely if Criterion A is met along with any two of criteria B, C, or D. Full PTSD requires all Criteria to be met.

Sexual behavior.

The ARBA also assessed sexual behavior among adolescents, including: lifetime participation in anal or vaginal sex, number of anal or vaginal sex acts during the past three months, and condom usage during sex in the past three months. We analyzed the average of Likert-scale scores for condom usage during anal and vaginal sex.

Data Analysis

Primary analyses compared parents and adolescents by retention items (attending all five sessions versus fewer than five sessions), and engagement items (facilitator and participant WAI scores) on demographics, mental health factors, perceptions of family functioning, attachment/bonding, parenting practices, substance use, adolescent sexual practices/behaviors, and readiness to change behaviors. T-tests were conducted to compare Likert-scaled measures that were appropriately treated as continuous variables by session attendance groups; the Satterthwaite adjustment was applied if diagnostic tests indicated unequal variances across groups. Since the WAI scores were continuous, we used a different analytic approach to examine potential correlates. Categorical measures, which mainly consisted of demographic characteristics, were treated as covariates of WAI scores in linear regression models. We examined Pearson correlation coefficients between measures that were appropriately treated as continuous measures and WAI scores. We report t-statistics or Chi-square statistics, degrees of freedom (df), and p-values. Each of the three parental retention items—session attendance, facilitator and participant WAI scores—were compared across 49 measures. Similarly, each of the three adolescent retention items were compared across 41 measures. In addition to the standard .05 alpha level, statistical significance is discussed in terms of the Holm-Bonferroni adjustment (Holm 1979) to give context to the large number of comparisons and Type I error rates. For each retention item, comparisons were ranked by their p-values. The alpha level for the smallest p-value was calculated as .05 / (n – 1 + 1), the alpha level for the next smallest p-value was calculated as .05 / (n – 2 + 1), and so forth, where n is the number of comparisons. For parents and adolescents, the smallest p-values needed to be less than alpha levels of approximately .0010 and .0012, respectively. We report mean differences (MD) between session attendance groups in terms of standardized effect sizes (ES) where SD is the pooled standard deviation between groups, ES = MD/SD. Following Cohen’s rules of thumb, ES of .1, .3, and .5 are considered to be small, medium, and large respectively (Cohen 1992).

Results

Retention and Engagement Outcome Analyses

Parents.

Table 2 shows all of the parent demographic characteristics and remaining measures (mental health, family, and alcohol and drug measures) that differed significantly by session attendance. Parents attending all five sessions versus fewer sessions reported a higher household income (Wilcoxon test, p = .03), less conflict-related reasoning on the Conflict Tactics Scale (t = −2.11, df = 66, p = .04), and higher anxiety on the Adult Attachment Scale, on average (t = 2.05, df = 66, p = .04).

Table 2.

Parent Demographics and Family Measures That Were Significantly Different by Session Attendance Out of 5 Possible Sessions

All 5 sessions (N = 52)
< 5 sessions (N = 16)
Mean SD Mean SD ESa
Demographics
Age 41.1 7.7 41.0 7.7 0.01
Male gender, % (n) 13% 7 6% 1
Married, % (n) 40% 21 38% 6
Race/Ethnicity, % (n)
  Hispanic 60% 31 50% 8
  Black/African American 21% 11 19% 3
  White/European American 17% 9 31% 5
  Other, Mixed Race 2% 1 0% 0
Primary language, % (n)
  English 62% 32 56% 9
  Spanish 37% 19 44% 7
  Other 2% 1 0% 0
Born in the U.S., % (n) 65% 34 56% 9
Years in the U.S. 21.6 9.2 18.9 6.7 0.32
Highest year of education 13.3 3.0 12.0 4.1 0.38
Currently employed, % (n) 67% 35 50% 8
Yearly income, Likert scale* 5.9 2.9 3.9 2.7 0.65
Child living w/ biol family, % (n) 75% 39 87.5% 14
Family measures
Reasoning, conflict tactics scale* 7.9 2.0 9.1 1.9 −0.58
Anxiety, adult attachment scale* 9.6 3.9 7.4 3.2 0.57
a

Effect size = (Mean of attending all 5 - Mean of attending < 5) / pooled SD

*

p < .05

Next we report relationships between WAI scores and parent measures, with significant findings summarized in Table 3. Higher facilitator-reported WAI scores were associated with a higher likelihood of reporting White/European American race/ethnicity versus other racial/ethnic groups (t = 2.44, df = 36, p = .02), less education (r = −.38, p = .02), a lower Adult Attachment closeness score (r = −.36, p = .03), and fewer mental health symptoms on the BSI global distress index (r = −.32, p = .047) and on the somatic (r = −.32, p = .048), phobia (r = −.42, p < .01), and psychoticism (r = −.45, p < .01) sub-scales.

Table 3.

Significant Associations between Participant and Facilitator WAI Scores and Parent Measures

r p-value
Facilitator-Reported WAI Scores
White/European American vs. other (ES)a 0.87 .02
Highest year of education −.38 0.02
Closeness, Adult Attachment scale −.36 .03
BSI
  Global Distress Index −.32 .047
  Somatic Score −.32 .048
  Phobia Score −.42 < .01
  Psychoticism Score −.45 <.01
Parent-Reported WAI Scores
Female vs. male gender (ES) 1.10 .03
  Mexican vs. non-Mexican Latino ethnicity (ES)a 1.07 .02
Money earned last month −.51 <.01
BSI Hostility Score .33 .04
  Laissez-Faire Family Style −.30 .06
a

Effect size = (Mean of the 1st group, e.g. White/European American - Mean of the 2nd group) / pooled SD

Higher participant-reported WAI scores were associated with a higher likelihood to be female (t = 2.19, df = 38, p = .03), and Mexican (t = 2.46, df = 37, p = .02) versus non-Mexican Hispanic ethnicity; participant-reported WAI scores did not significantly differ between Non-Hispanic and Hispanic ethnicity. Furthermore, higher participant-reported WAI scores were associated with receiving less money last month (r = −.51, p < .01), and increased levels of hostility on the BSI (r = .33, p = .04). No other significant differences were found for parent demographics, mental health, sexual behavior, and substance use in comparisons with session attendance and WAI scores. Based on the Holm-Bonferroni adjustment, none of the parent results were statistically significant.

Adolescents.

Table 4 shows all of the adolescent demographic characteristics and remaining measures that differed significantly by session attendance. Adolescents attending all five sessions versus fewer sessions reported more mental health symptoms on the BSI, both on the global distress index (t = 2.86, df = 42.5, p < .01), and on the depression (t = 2.76, df = 53.1, p < .01), anxiety (t = 2.11, df = 66, p = .04), somatization (t = 4.33, df = 65.9, p < .01),obsessive-compulsive (t = 2.94, df = 40.2, p < .01), phobic anxiety (t = 2.95, df = 58.8, p < .01), and psychoticism (t = 2.24, df = 41.1, p = .03) subscales. A higher percentage of males (93%; n = 14 of 15) attended all five sessions than females (73%; n = 38 of 53), though this difference was not statistically significant (Fisher’s Exact test, p = .10).

Table 4.

Adolescent Demographics and Mental Health Measures that Were Significantly Different by Session Attendance Out of 5 Possible Sessions

All 5 sessions (N = 52)
< 5 sessions (N = 16)
Mean SD Mean SD ESa
Demographics
Age 14.8 1.3 14.5 1.4 0.25
Female gender, % (n) 73% 38 94% 15
Race/Ethnicity, % (n)
  Hispanic 65% 34 50% 8
  Black/African American 15% 8 19% 3
  White/European American 10% 5 13% 2
  Other, Mixed Race 10% 5 19% 3
Primary language, % (n)
  English 90% 47 75% 12
  Spanish 10% 5 19% 3
  Other 0% 0 6% 1
Sexual orientation
  Bisexual 10% 5 19% 3
  Heterosexual 90% 47 81% 13
Mental health (BSI)
  Global** 1.13 0.64 0.76 0.38 0.62
  Depression** 1.20 0.87 0.76 0.42 0.55
  Anxiety* 1.04 0.75 0.61 0.53 0.61
  Somatization** 0.88 0.79 0.34 0.25 0.73
  Obsessive-compul sive** 1.40 0.84 0.89 0.53 0.62
  Phobic anxiety** 0.78 0.75 0.39 0.32 0.57
  Psychoticism* 1.03 0.85 0.64 0.53 0.49
a

Effect size = (Mean of attending all 5 - Mean of attending less than 5) / pooled SD

*

p < .05;

**

p < .01

Next we report relationships between WAI scores and adolescent measures, with significant findings summarized in Table 5. Higher WAI scores were observed for females versus males (t = 2.39, df = 36, p = .02 for facilitator scores and t = 5.54, df = 38, p < .01 for participant scores) and for URICA contemplation scores (r = .40, p = .01 for facilitator scores and r = .52, p < .01 for participant scores). Higher participant-reported WAI scores were also associated with higher URICA action (r = .52, p < .01) and readiness scores (r = .55, p < .01), as well as lower precontemplation scores (r = −.34, p = .03). Adolescents talking more about sex, alcohol, and drugs with their parents in the past three months according to the TAAPSS had higher facilitator-reported WAI scores (r = .37, p = .02). No other significant differences were found for adolescent demographics, mental health, sexual behavior, and substance use in comparisons with session attendance and WAI scores. After Holm-Bonferroni adjustment, statistical significance remained for mean BSI somatization score differences by session attendance, as well as gender, URICA contemplation and action score differences by participant-reported WAI scores.

Table 5.

Significant Associations between Participant and Facilitator WAI Scores and Adolescent Measures

r p-value
Facilitator-Reported WAI Scores
Female gender vs. male (ES)a 0.86 .02
URICA
  Contemplation Score .40 .01
  Readiness Score .31 .06
TAAPSS Score .37 .02
Adolescent-Reported WAI Scores
Female vs. male gender (ES)a 5.54 <.01
Anal or Vaginal Sex (yes) vs. no (ES)a −0.54 .09
URICA
  Contemplation Score .52 <.01
  Action Score .52 <.01
  Readiness Score .55 <.01
  Pre-contemplation Score −.34 .03
  Maintenance Score .30 .06
a

Effect size = (Mean of the 1st group, e.g. Female gender – Mean of the 2nd group) / pooled SD

Discussion

There are several important results from these analyses. Parents with more income and less perceived family conflict were more likely to complete the intervention. These findings are in keeping with several other studies (Kazdin, Holland, and Crowley 1997; Snell-Johns, Mendez, and Smith 2004), suggesting that families with less hardship and distress can be better retained in interventions. Relatively more interesting is the finding that the parents who completed the intervention also reported more anxiety symptoms, suggesting that some parents with greater need for intervention were actually better retained.

With respect to adolescents, the retention results are quite surprising. Adolescents who completed the intervention, relative to those who did not, reported more depressive, anxiety, somatizing, obsessive-compulsive, phobic, and psychotic symptoms. This suggests that, as with the parents in this study, adolescents with greater distress and thus greater need were more apt to finish the intervention. This finding differs from previous research on family interventions that more often reports families who have more distress have lowered retention in interventions (Snell-Johns et al. 2004). But, research on youth serviced by the public sector (e.g., juvenile justice, child welfare, and alcohol and drug abuse), also reports a similar pattern of higher use of mental health services (Garland et al. 2005).

There are a number of reasons why retention of at-risk participants, such as homeless adolescents, is challenging for prevention programs, including psychological distress, systematic and societal barriers (Orrell-Valente et al. 1999). However, for the adolescents in this study, a distressed emotional state seemed to be a potential mechanism for retention. This suggests a number of areas for further research on how greater stress may be associated with completing the intervention, such as through the related increased awareness of the need for support, higher motivation, and/or experience of more immediate benefits. Compared to other family interventions, STRIVE may be more acutely culturally responsive to the needs of distressed adolescents. This may be an artifact of both the curriculum and training of the facilitators. STRIVE facilitators are trained in how to implement the intervention in a culturally-humble way while keeping health disparities, sociopolitical climate and culture in mind. The curriculum is manualized to maintain fidelity, but it is also highly encouraged that the facilitator individualizes the examples to the family’s culture. Establishing this positive cultural response may have assisted with retention. This is consistent with emerging research on being culturally responsive in engaging racial/ethnic minorities (Fryer et al. 2016).

The process of engagement as assessed by the therapeutic alliance was sensitive to several individual-level differences for parents. From the standpoint of the facilitators, a greater alliance was perceived with White/European American parents and parents with fewer mental health symptoms. This is consistent with prior work that suggests engaging with racial/ethnic minority families and families who are in more distress is more challenging (Garland et al. 2005; Kazdin et al. 1997). Interestingly, however, parents who identified as racial/ethnic minorities, women, those with lower income and higher hostility symptoms reported an increased sense of alliance with the facilitators. Fully understanding, for example, why ethnic minority parents report greater alliance for themselves requires more research in areas such as access. Ethnic minority parents, whom often have limited access to interventions, may have had positive perceptions of the alliance because of the accessibility of the intervention. Thus, in the current study, being more distressed (i.e. lower income, more hostility) or being a racial/ethnic minority person was not a barrier to alignment. Such findings are uncommon in family interventions, challenging the notion that the neediest families are more difficult to engage in building a relationship with the facilitators. This result speaks to the important role the facilitator(s) have of engaging families of “high need” and knowing that alliances can indeed be fostered between the facilitator and parents of at-risk youth. This study supports the notion that the parent buy-in to any intervention is essential in the retention and completion of the program. In a larger scale, this can assist with lowering the racial and ethnic disparities in mental health services (Garland et al. 2005). The findings around the therapeutic alliance and engagement with the adolescents were less conclusive. From the perspective of both the facilitators and the youth, female participants built more productive therapeutic alliances. Adolescents who reported greater comfort discussing sex with their parents were identified by facilitators as having a stronger therapeutic alliance. This last finding may suggest that youth who have an easier time discussing difficult topics may be more amenable to family interventions because they are open and “ready” to discuss difficult topics such as family conflict. The remainder of the findings were not significant at the conventional p < .05 level, and we hesitate to interpret them further.

There are a few limitations to this study. First, these data come from an efficacy trial of a family intervention, not an efficacy trial of intervention implementation. As such, we have limited information on key engagement processes aside from the therapeutic alliance. Second, numerous statistical tests were conducted on data from a relatively small randomized control trial, making it difficult to adjust for Type I error without preventing us from reporting on relationships which exist in the population (Type II error). Third, on a related point, we focus on bi-variate associations and not multivariate models because these analyses are both exploratory and have limited statistical power for such models. In addition, small Cronbach’s alphas less than 0.70 were found for a number of scales, indicating less than adequate reliability between scale items; especially low alpha values are noted for the Conflicts Tactics Reasoning scale, the discomfort-in-closeness subscale, and a number of adolescent-assessed components of Family Functioning. Last, the use of self-report measures was a limitation of this study. Self-report measures rely on the participant’s report of their symptoms, behaviors and experiences. Honesty, introspective ability and interpretation ability can influence participants’ responses. The implication is that self-report measures may not be assessing the underlying constructs they were intended to capture in this sample, and the results should be interpreted with caution. Despite these limitations, we believe these data are informative for several reasons: relatively few studies have looked at retention and engagement in the context of prevention programs (Ingoldsby 2010), and fewer still in HIV prevention programs (Kapungu et al. 2012); no studies have looked at retention and engagement in prevention programs with homeless youth (to our knowledge); we found some very informative counter-intuitive findings with respect to family distress which suggest that for these families who are almost all distressed, some modest increased levels of additional distress may be a motivation for retention and engagement in treatment.

The implications of these findings are significant in understanding the complexities of engagement for at-risk youth and their families. It is also important to note that both participant and provider perceptions are important in development of a strong therapeutic alliance. Given providers’ perception that their alliances were stronger with White/European American families and those with fewer mental health symptoms, these findings warrant further exploration of the development of cultural humility, awareness training, and improving mental health literacy for facilitators. Because working with families who may have more distress, economically and health wise, is perceived to be more challenging, preparing facilitators to work with these families is paramount.

The fact that families who were experiencing more distress had better therapeutic alliance than their counterparts suggests that there may be additional need for the development of psychoeducational interventions for families in crisis. More work needs to be done, but we can say that brief psychoeducational family interventions can be engaging and efficacious for at-risk adolescents and their families, but for these to be effective, we may need to determine who among this population is the best target for these types of family interventions. This study contributes to understanding how to engage and retain underserved populations in family interventions within the Implementation Phase of the TSci Impact Framework (Spoth et al. 2013). These findings can help in the development of better strategies for improving participation in family-based interventions that can improve the health outcomes of young people over their lifetimes.

Supplementary Material

11121_2020_1157_MOESM1_ESM

Acknowledgments

Funding: This research was supported by grants from the National Institute on Drug Abuse (DA035692, DA024955), the National Institute of Mental Health (MH70322), and the National Institute on Minority Health and Health Disparities (P20MD000182).

Footnotes

Compliance with Ethical Standards

Disclosure of potential conflicts of interest: The authors declare no conflict of interest.

Ethical approval: All data collection procedures were carried out with approval from, and in compliance with, the Institutional Review Board of the University of California, Los Angeles.

Informed consent: Informed consent was obtained from all individual participants in the study.

Conflict of Interest: The authors declare that they have no conflict of interest.

Publisher's Disclaimer: This Author Accepted Manuscript is a PDF file of a an unedited peer-reviewed manuscript that has been accepted for publication but has not been copyedited or corrected. The official version of record that is published in the journal is kept up to date and so may therefore differ from this version.

Contributor Information

Norweeta G. Milburn, University of California Los Angeles

Alexandra M. Klomhaus, University of California Los Angeles

W. Scott Comulada, University of California Los Angeles.

Susana A. Lopez, University of California Los Angeles

Eraka Bath, University of California Los Angeles.

Bita Amani, Charles Drew University of Medicine and Science.

Jessica Jackson, University of California Los Angeles.

Alex Lee, University of Southern California Suzanne Dworak-Peck School of Social Work.

Eric Rice, University of Southern California Suzanne Dworak-Peck School of Social Work.

Alan Semaan, University of California Los Angeles.

Bo-Kyung Elizabeth Kim, University of Southern California Suzanne Dworak-Peck School of Social Work.

References

  1. Bloom BL (1985). A factor analysis of self-report measures of family functioning. Family Process, 24, 255–239. doi: 10.1111/j.1545-5300.1985.00225.x [DOI] [PubMed] [Google Scholar]
  2. Bray JH, & Pequegnat W. (2012). Statistical challenges in studying complex and changing families. AIDS Behavior, 16(2), 441–51. doi: 10.1007/s10461-011-9881-6 [DOI] [PubMed] [Google Scholar]
  3. Busseri MA, & Tyler JD (2003). Interchangeability of the Working Alliance Inventory and Working Alliance Inventory, Short Form. Psychological Assessment, 15, 193–197. [DOI] [PubMed] [Google Scholar]
  4. Coatsworth JD, Duncan LG, Pantin H, & Szapocznik J. (2006). Patterns of retention in a preventive intervention with ethnic minority families. The Journal of Primary Prevention, 27(2), 171–193. doi: 10.1007/s10935-005-0028-2 [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Coatsworth JD, Hemady KT, & George MS (2018). Predictors of group leaders’ perceptions of parents’ initial and dynamic engagement in a family preventive intervention. Prevention Science, 19(5), 609–619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cohen J. (1992). “A power primer”. Psychological Bulletin, 112(1), 155–159. [DOI] [PubMed] [Google Scholar]
  7. Collins NL, & Read SJ (1990). Adult attachment, working models, and relationship quality in dating couples. Journal of Personality and Social Psychology, 58(4), 644–663. [DOI] [PubMed] [Google Scholar]
  8. Derogatis LR (1993). BSI Brief Symptom Inventory: Administration, Scoring, and Procedure Manual (4th Ed.). Minneapolis, MN: National Computer Systems. [Google Scholar]
  9. Donenberg GR, Emerson E, Bryant FB, Wilson H, & Weber-Shifrin E. (2001). Understanding AIDS-risk behavior among adolescents in psychiatric care: links to psychopathology and peer relationships. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 642–653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Elvins R, & Green J. (2008). The conceptualization and measurement of therapeutic alliance: An empirical review. Clinical Psychology Review, 28(7), 1167–1187. [DOI] [PubMed] [Google Scholar]
  11. Fryer CS, Passmore SR, Maietta RC, Petruzzelli J, Casper E, Brown NA, et al. (2016). The symbolic value and limitations of racial concordance in minority research engagement. Qualitative Health Research, 26(6), 830–841. 10.1177/1049732315575708 [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Garland AF, Lau AS, Yeh M, McCabe KM, Hough RL, & Landsverk JA (2005). Racial and ethnic differences in utilization of mental health services among high-risk youths. American Journal of Psychiatry, 162(7), 1336–1343. [DOI] [PubMed] [Google Scholar]
  13. Gavin DR, Ross HE, & Skinner HA (1989). Diagnostic Validity of the Drug Abuse Screening Test in the Assessment of DSM-III Drug Disorders. British Journal of Addiction, 84, 301–307. [DOI] [PubMed] [Google Scholar]
  14. Gratz KL, & Roemer L. (2004). Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the Difficulties in Emotion Regulation Scale. Journal of Psychopathology and Behavioral Assessment, 26, 41–54. [Google Scholar]
  15. Holm S. (1979). A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics, 6(2), 65–70. [Google Scholar]
  16. Ingoldsby E. (2010). Review of interventions to improve family engagement and retention in parent and child mental health programs. Journal of Child & Family Studies, 19(5), 629–645. doi: 10.1007/s10826-009-9350-2 [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kapungu C, Nappi C, Thakral C, Miller S, Devlin C, McBride C, et al. (2012). Recruiting and retaining high-risk adolescents into family-based HIV prevention intervention research. Journal of Child & Family Studies, 21(4), 578–588. [Google Scholar]
  18. Kazdin AE, Holland L, & Crowley M. (1997). Family experience of barriers to treatment and premature termination from child therapy. Journal of Consulting and Clinical Psychology, 65(3), 453–463. [DOI] [PubMed] [Google Scholar]
  19. Martino S, Grilo CM, & Fehon DC (2000). Development of the Drug Abuse Screening Test for adolescents (DAST-A). Addictive Behaviors, 25, 57–70. [DOI] [PubMed] [Google Scholar]
  20. Mauricio AM, Gonzales N, & Sandler IN (2018). Preventive parenting interventions: Advancing conceptualizations of participation and enhancing reach. Prevention Science, 19, 603–608. [DOI] [PubMed] [Google Scholar]
  21. McConnaughy EA, Prochaska JO, & Velicer WF (1983). Stages of change in psychotherapy: Measurement and sample profiles. Psychotherapy: Theory, Research, and Practice, 20, 368–375. [Google Scholar]
  22. Milburn NG, Iribarren FJ, Rice E, Lighfoot M, Solorio R, Rotheram-Borus MJ, et al. (2012). A family intervention to reduce sexual risk behavior, substance use, and delinquency among newly homeless youth. Journal of Adolescent Health, 50(4), 358–364. doi: 10.1016/j.jadolhealth.2011.08.009 [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Milburn NG, & Lightfoot M. (2016). Improving the participation of families of color in evidence-based interventions: Challenges and lessons learned In Zane N, Bernal G, Leong FL. (Eds.), Evidence-based psychotherapy practice with ethnic minorities: Culturally informed research and clinical strategies (pp.273–287). Washington, DC, US: American Psychological Association. doi: 10.1037/14940-013 [DOI] [Google Scholar]
  24. Milburn NG, Rice E, Rotheram-Borus MJ, Mallett S, Rosenthal D, Batterham P, et al. (2009). Adolescents exiting homelessness over two years: The risk amplification and abatement model. Journal of Research on Adolescence, 19(4), 762–785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Milburn NG, Rosenthal D, Rotheram-Borus MJ, Mallett S, Batterham P, Rice E, & Solorio R. (2007). Newly homeless youth typically return home. Journal of Adolescent Health, 40(6), 574–576. doi: 10.1016/j.jadohealth.2006.12.017 [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Murry VM, Berkel C, & Liu N. (2018). The closing digital divide: Delivery modality and family attendance in the Pathways for African American Success (PAAS) Program. Prevention Science, 19, 642–651. 10.1007/s11121-018-0863-z [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Orrell-Valente JK, Pinderhughes EE, Valente E Jr., Laired RD, Bierman KL, Coie JD, et al. (1999). If it’s offered, will they come? Influences on parents’ participation in a community-based conduct problems prevention program. American Journal of Community Psychology, 27, 753–784. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Parker G, Tupling H, & Brown LB (1979). A Parental Bonding Instrument. British Journal of Medical Psychology, 52, 1–10. doi: 10.1111/j.2044-8341.1979.tb02487.x [DOI] [Google Scholar]
  29. Pergamit M, Gelatt J, Straford B, Beckwith S, & Martin MC (2016). Family interventions for youth experiencing or at risk of homelessness. Washington, DC: Urban Institute. [Google Scholar]
  30. Rotheram-Borus MJ, Goldstein AM, & Elkavich AS (2002). Treatment of suicidality: A family intervention for adolescent suicide attempters In Hofmann SG & Thompson MC (Eds.), Treating chronic and severe mental disorders: A handbook of empirically supported interventions (pp. 191–212). New York, NY, US: Guilford Press. [Google Scholar]
  31. Selzer ML (1971). The Michigan Alcoholism Screening test (MAST): The quest for a new diagnostic instrument. American Journal of Psychiatry, 127(12), 1653–1658. [DOI] [PubMed] [Google Scholar]
  32. Selzer ML, Vinokur A, van Rooijen L. (1975). A self-administered Short Michigan Alcoholism Screening Test (SMAST). Journal of Studies on Alcohol, 36, 117–126. [DOI] [PubMed] [Google Scholar]
  33. Skinner HA (1982). The Drug Abuse Screening Test. Addictive Behaviors, 7, 363–371. [DOI] [PubMed] [Google Scholar]
  34. Snell-Johns J, Mendez JL, & Smith BH (2004). Evidenced-based solutions for overcoming access barriers, decreasing attrition, and promoting change with underserved families. Journal of Family Psychology, 18(1), 19–35. doi: 10.1037/0893-3200.18.1.19 [DOI] [PubMed] [Google Scholar]
  35. Spoth R, & Redmond C. (2000). Research on family engagement in preventive interventions: Toward improved use of scientific findings in primary prevention practice. The Journal of Primary Prevention, 21(2), 267–284. doi: 10.1023/A:1007039421026 [DOI] [Google Scholar]
  36. Spoth R, Rohrbach LA, Greenberg M, Leaf P, Brown CH, Fagan A, et al. (2013). Addressing core challenges for the next generation Type 2 translational research and systems: The Translation Science to Population Impact (TSci Impact) Framework. Prevention Science, 14, 319–351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Staudt M. (2007). Treatment engagement with caregivers of at-risk children: Gaps in research and conceptualization. Journal of Child and Family Studies, 16(2), 183–196. [Google Scholar]
  38. Steinberg AM, Brymer M, Decker K, & Pynoos RS (2004). The UCLA PTSD Reaction Index. Current Psychiatry Reports, 6, 96–100. [DOI] [PubMed] [Google Scholar]
  39. Strauss MA (1979). Measuring intrafamily conflict and violence: The Conflict Tactics Scales. Journal of Marriage and the Family, 41, 75–88. [Google Scholar]
  40. Thompson S, Bender K, Lantry J, & Flynn P. (2007). Treatment engagement: Building therapeutic alliance in home-based treatment with adolescents and their families. Contemporary Family Therapy: An International Journal, 29(1/2), 39–55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Tyler KA, & Schmitz RM (2013). Family histories and multiple transitions among homeless young adults: Pathways to homelessness. Children and Youth Services Review, 35(10), 1719–1726. doi: 10.1016/j.childyouth.2013.07.014 [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Winslow EB, Bonds D, Wolchik S, Sandler I, & Braver S. (2009). Predictors of enrollment and retention in a preventive parenting intervention for divorced families. Journal of Primary Prevention, 30(2), 151–172. doi: 10.1007/s10935-009-0170-3 [DOI] [PMC free article] [PubMed] [Google Scholar]

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