Table 5.
Acute toxicity and distribution of the compounds identified in the blood of powder-treated group.
| No. | Compounds | LD50 (Oral) a | Distribution b | Content c |
|---|---|---|---|---|
| M20 | dl-Camphor | mouse, 1310 mg/kg [35] | P (FE, UR, BL, HE, LU, LI, KI, ST, IN) D (FE, UR, LI, KI, ST, IN) |
0.11% |
| M37 | Estragole | mouse, 1250 mg/kg [36] | P (BL, BR, HE, LU, SP, LI, KI, ST, IN) D (n.d.) |
0.28% |
| M44 | Borneol | mouse, 1059 mg/kg [35] | P (FE, UR, BL, SP, KI, ST, IN) D (FE, UR, KI, ST) |
0.12% |
| M64 | safrole | mouse, 2350 mg/kg [33,36] | P (FE, UR, BL, BR, HE, LU, SP, LI, KI, ST, IN) D (FE, UR, SP, LI, KI, IN) |
23.74% |
| M79 | Methyleugenol | rat, 1179 mg/kg [33] | P (FE, UR, BL, BR, HE, LU, SP, LI, KI, ST, IN) D (FE, UR, SP, LI, KI, ST, IN) |
4.69% |
| M104 | Piperonal | rat, 2700 mg/kg [37] | P (UR, BL) D (UR, BL) |
0.07% |
| M112 | β-Asarone | mouse, 418 mg/kg [38] | P (BL, LI, KI, ST) D (ST) |
0.04% |
| M122 | 3,4-Methylenedioxypropiophenone | mouse, 2150 mg/kg [39] | P (FE, UR, BL, BR, HE, LU, SP, LI, KI, ST, IN) D (FE, UR, BL, BR, HE, LU, SP, LI, KI, ST, IN) |
1.58% |
| M131 | 1-(3,4-Methylenedioxyphenyl)-propane-1-ol | mouse, 720 mg/kg [40] | P (FE, BL, SP, LI, KI, IN) D (FE, UR, LI, KI, ST, IN) |
0.15% |
a The LD50 values were queried in PubChem (https://pubchem.ncbi.nlm.nih.gov/). b Distribution in this study, P: powder-treated group; D: decoction-treated group; FE: feces; UR: urine; BL: blood; BR: brain; HE: heart; LU: lung; SP: spleen; LI: liver; KI: kidney; ST: stomach; IN: small intestine. c The relative content in the blood of powder-treated group.