Table 2.

ECM components involved in angiogenesis.

Proangiogenic Factor		Antiangiogenic Factor
Factor	Biological Effect	Factor	Biological Effect
Collagen IV	Low dose: neovessel elongation and survival ↑, high dose: neovessel stability ↑	Endostatin	Proliferation and migration of endothelial cells ↓, adipogenesis ↓
Laminin	Proliferation and migration of endothelial cells ↑	Arresten, canstatin, and tumstatin	Proliferation and migration of endothelial cells ↓, microvessel density ↓, VEGF ↓
Fibronectin	Migration and survival of endothelial cells ↑, number of microvascular cells ↑
Hyaluronan fragments	Proliferation and migration of endothelial cells ↑, bFGF-induced neovascularization ↑	Laminin fragments	Tube formation and migration of endothelial cells ↓, apoptosis of endothelial cells ↑
Osteopontin	VEGF release ↑, migration and tube formation of endothelial cells ↑	Fibronectin and anastellin	Blood vessel density ↓
Elastin and elastokine	Tube formation of endothelial cells ↑, ProMMP-2 expression and activity ↑	Hyaluronan	Proliferation, migration, and capillary tube formation of endothelial cells ↑