Table 1.
Isoform selectivity of hybrids 7 and 8 against HDACs and CDKs.
| Hybrid | IC50 (nM) | |||||||
|---|---|---|---|---|---|---|---|---|
| HDAC1 | HDAC2 | HDAC3 | HDAC6 | HDAC8 | CDK1 | CDK2 | CDK4,6,7 | |
| 7 | 240 | 0.24 | >1000 | >1000 | >1000 | 12.58 | 0.56 | >1000 |
| 8 | 6.4 | 0.25 | 45 | >1000 | >1000 | 8.63 | 0.30 | >1000 |
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