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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Bioessays. 2020 Mar 20;42(5):e1900192. doi: 10.1002/bies.201900192

Fig. 2. PRC1-catalytic activity is essential for PRC1-mediated transcriptional repression.

Fig. 2.

(A) Venn diagram showing the overlap in significantly upregulated genes in epidermal progenitors for the indicated genotypes that are marked by H2AK119ub and H3K27me3 in epidermal progenitors. (B) Integrative Genomics Viewer (IGV) ChIP-seq and RNA-seq browser views for the indicated markers and genotypes in epidermal progenitors. Note that some genes co-marked by H2AK119ub and H3K27me3 are de-repressed only upon loss of PRC1-catalytic or -global activities, but not upon loss of PRC2 activity. In addition, note that loss of PRC1-catalytic activity does not impair RING1B binding to those genes in epidermal progenitors. Data was obtained from the Gene Expression Omnibus (GEO) database (GSE112460) and was analyzed as previously described.[21]