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Comparison of the SERS spectrum of the CSF samples infected by N. meningitidis (a) versus that of the normal (control) CSF samples (b). Samples of CSF were deposited onto the Si/ZnO/Au substrate and measured in situ. The inset shows the SERS spectrum of neopterin adsorbed onto the Si/ZnO/Au substrate from 35.0 nmol/L neopterin solution in a PBS buffer. The presented SERS spectra were averaged from ten measurements in different places of the SERS nanostructures [126].
