Grundy, G.J. and Parsons, J.L. (2020) Base excision repair and its implications to cancer therapy. Essays Biochem. https://doi.org/10.1042/EBC20200013
During the production process errors were introduced into Table 1. The correct version of Table 1 appears here.
Table 1. DNA glycosylases: substrates, inhibitors and synthetic lethal partners.
| DNA Glycosylase | Substrate | Inhibitor | Synthetic lethal partner |
|---|---|---|---|
| Monofunctional | |||
| UNG | |||
| Uracil DNA glycosylase | Uracil | APOBEC3B | |
| SMUG1 | |||
| Single-strand selective monofunctional uracil DNA glycosylase | Uracil, 5-formyluracil, 5-hydroxyuracil and 5-hydroxymethyluracil | ||
| TDG | |||
| G/T Mismatch specific thymine DNA glycosylase | 5-Formylcytosine and 5-carboxylcytosine in CpG. G:T and U:T mismatches | ||
| MBD4 | |||
| methyl-CpG binding domain protein 4 | G:T mismatches within methylated and unmethylated CpG sites. Uracil or 5-fluorouracil in G:U mismatches | ||
| MPG | |||
| N-methylpurine DNA glycosylase | 3-methyladenine, and 7-methylguanine | ||
| MUTYH | |||
| Adenine DNA glycosylase | 7,8-Dihydro-8-oxoguanine (8-oxoG):adenine | ||
| Bifunctional | |||
| NTH1 | |||
| Endonuclease III-like protein 1 | Oxidised pyrimidines, thymine glycol | ||
| OGG1 | |||
| 8-oxoguanine DNA glycosylase 1 | 8-OxoG, formamidopyrimidine (Fapy)G | O8 | MMR deficiency |
| SU0268 | |||
| TH5487 | |||
| Endonuclease VIII-like | |||
| NEIL1 | Thymine glycol, Fapy, 5-hydroxyuracil | 2TX | FANCG |
| NEIL2 | 5-Hydroxyuracil | ||
| NEIL3 | Spiroiminodihydantoin and guanidinohydantoin |