Table 1.

Effects of GHRH-R antagonists in lung inflammation and cancer models.

GHRH-R Antagonists	Model System	Pathways Implicated in Effects	Potential Effects	Reference
MZ-5-156	Lung cancer	AMPK ↑ Akt/mTOR ↓ GSK3β ↓	Anti-proliferative	[15]
MIA-602	Lung endothelial cells	ERK ↓ JAK2/STAT3 ↓ p53 ↑ AMPK ↑	anti-inflammatory	[16]
MIA-602	Mouse lung and fibroblasts	ERK ↑ Akt ↓	anti-inflammatory, anti-fibrotic, pro-apoptotic	[17]